Indeno[1,2-b]pyrrol-4(1H)-one, 3-acetyl-2-methyl-1-(phenylmethyl)-

Base Information

• Chemical Name: Indeno[1,2-b]pyrrol-4(1H)-one, 3-acetyl-2-methyl-1-(phenylmethyl)-
• CAS No.: 112807-62-2
• Molecular Formula: C21H17NO2
• Molecular Weight: 315.371
• Mol file: 112807-62-2.mol

Synonyms:

Chemical Property of Indeno[1,2-b]pyrrol-4(1H)-one, 3-acetyl-2-methyl-1-(phenylmethyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Indeno[1,2-b]pyrrol-4(1H)-one, 3-acetyl-2-methyl-1-(phenylmethyl)-

There total 4 articles about Indeno[1,2-b]pyrrol-4(1H)-one, 3-acetyl-2-methyl-1-(phenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

indan-1,2,3-trione hydrate (485-47-2) + acetylacetone (123-54-6,81235-32-7) + benzylamine (100-46-9) → 3-acetyl-1-benzyl-2-methylindeno[1,2-b]pyrrol-4(1H)-one (112807-62-2)

Guidance literature:

acetylacetone; benzylamine; In acetonitrile; at 20 ℃; for 0.5h;

indan-1,2,3-trione hydrate; In acetonitrile; at 20 ℃; for 0.25h;

With triphenylphosphine; In acetonitrile; at 20 ℃; for 3h;

DOI:10.1007/s10593-018-2388-6

Reference yield: 55.6%

1-Benzyl-2-methyl-4-oxoindeno<1,2-b>pyrrole (112807-65-5) + acetyl chloride (75-36-5) → 3-acetyl-1-benzyl-2-methylindeno[1,2-b]pyrrol-4(1H)-one (112807-62-2)

Guidance literature:

With aluminium trichloride; In benzene; 1.) 20 deg C, 20 min, 2.) 20 deg C, 1.5 h; 50-55 deg C, 0.5 h;

DOI:10.1007/BF00758135

Reference yield:

1-Benzyl-2-methyl-4-oxo-1,4-dihydro-indeno[1,2-b]pyrrole-3-carboxylic acid ethyl ester (82577-14-8) → 3-acetyl-1-benzyl-2-methylindeno[1,2-b]pyrrol-4(1H)-one (112807-62-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 27.5 percent / pyridine chlorohydrate / 0.02 h / 200 °C

2: 55.6 percent / AlCl₃ / benzene / 1.) 20 deg C, 20 min, 2.) 20 deg C, 1.5 h; 50-55 deg C, 0.5 h

With aluminium trichloride; pyridine hydrochloride; In benzene;

DOI:10.1007/BF00758135

upstream raw materials:

1-Benzyl-2-methyl-4-oxoindeno<1,2-b>pyrrole

acetyl chloride

1-Benzyl-2-methyl-4-oxo-1,4-dihydro-indeno[1,2-b]pyrrole-3-carboxylic acid ethyl ester

1-Benzyl-2-methyl-4-oxo-1,4-dihydro-indeno[1,2-b]pyrrole-3-carboxylic acid

Refernces

• 1、 Nesterova, I. N.,Mezentseva, M. V.,Nikolaeva, I. S.,Pushkina, T. V.,Golovanova, E. A.,Fomina, A. N.. "SYNTHESIS AND ANTIVIRAL ACTIVITY OF THE BISULFITE DERIVATIVE OF 1-PHENYL-2-METHYL-4-OXOINDENOPYRROLYL-3-GLYOXAL". . p. 725 - 728. Retrieved 2007/10/02.