N-(morpholin-2-ylmethyl)acetamide

Base Information

• Chemical Name: N-(morpholin-2-ylmethyl)acetamide
• CAS No.: 112913-95-8
• Molecular Formula: C7H14N2O2
• Molecular Weight: 158.2
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID101302496
• ChEMBL ID: CHEMBL4514798
• Mol file: 112913-95-8.mol

Synonyms:N-(morpholin-2-ylmethyl)acetamide;112913-95-8;N-[(morpholin-2-yl)methyl]acetamide;2-(N-acetylaminomethyl)morpholine;2-acetylaminomethylmorpholine;SCHEMBL1501987;CHEMBL4514798;N-(2-Morpholinylmethyl)acetamide;UGPSGKBXOZVVCV-UHFFFAOYSA-N;DTXSID101302496;MFCD12144046;AKOS009249852;AS-37004;CS-0217626;EN300-80139;Z439694282

Chemical Property of N-(morpholin-2-ylmethyl)acetamide

Chemical Property:

• PSA: 50.36000
• LogP: -0.16940
• XLogP3: -1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 158.105527694
• Heavy Atom Count: 11
• Complexity: 138

Purity/Quality:

99% ^*data from raw suppliers

N-(Morpholin-2-ylmethyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NCC1CNCCO1

Technology Process of N-(morpholin-2-ylmethyl)acetamide

There total 5 articles about N-(morpholin-2-ylmethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(N-acetylaminomethyl)-4-benzylmorpholine (112913-96-9) → 2-(N-acetylaminomethyl)morpholine (112913-95-8)

Guidance literature:

palladium-carbon; In ethyl acetate;

Reference yield: 99.0%

N-((4-benzylmorpholin-2-yl)methyl)acetamide trifluoroacetate → 2-(N-acetylaminomethyl)morpholine (112913-95-8)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃;

Reference yield:

N-benzyl-2-chloromethylmorpholine (40987-25-5,186293-54-9) → 2-(N-acetylaminomethyl)morpholine (112913-95-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 87 percent / dimethylformamide / 5 h / Heating

2: 83.4 percent / hydrazine monohydrate / ethanol / 4 h / Heating

3: 82.3 percent / toluene / 3 h / Ambient temperature

4: 91.9 percent / hydrazine monohydrate / 10percent Pd-C / propan-2-ol / 1.5 h / Heating

With hydrazine hydrate; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide; isopropyl alcohol; toluene;

DOI:10.1021/jm00062a007

upstream raw materials:

2-(N-acetylaminomethyl)-4-benzylmorpholine

N-benzyl-2-chloromethylmorpholine

N-[(4-benzyl-2-morpholinyl)methyl]phthalimide

(4-benzylmorpholin-2-yl)methanamine

Downstream raw materials:

2-<(acetylamino)methyl>-4-(4-fluorobenzyl)morpholine

2-acetylaminomethyl-4-[{1-(tert-butoxycarbonyl)-4-piperidinyl}methyl]morpholine

4-Amino-N-(4-benzo[d]isoxazol-3-ylmethyl-morpholin-2-ylmethyl)-5-chloro-2-methoxy-benzamide

4-Amino-5-chloro-N-{4-[6-(4-fluoro-phenoxy)-hexyl]-morpholin-2-ylmethyl}-2-methoxy-benzamide

Refernces

• 1、 -. "Indolobenzazepine HCV NS5B inhibitors". Page/Page column 239-240. . Retrieved 2008/06/13.
• 2、 Araki,Kuroda,Uemori,Moriguchi,Ikeda,Hirayama,Yokoyama,Iwao,Yakushiji. "Quinolone antimicrobial agents substituted with morpholines at the 7- position. Syntheses and structure-activity relationships". . p. 1356 - 1363. Retrieved 2007/10/02.