3-chloro-5-nitro-aniline

Base Information

• Chemical Name: 3-chloro-5-nitro-aniline
• CAS No.: 5344-44-5
• Molecular Formula: C6H5 Cl N2 O2
• Molecular Weight: 172.571
• Hs Code.: 2921420090
• Mol file: 5344-44-5.mol

Synonyms:Aniline,3-chloro-5-nitro- (8CI); 3-Chloro-5-nitroaniline; 5-Chloro-3-nitroaniline; NSC1117

Chemical Property of 3-chloro-5-nitro-aniline

Chemical Property:

• Vapor Pressure: 0.000144mmHg at 25°C
• Boiling Point: 332.7°Cat760mmHg
• Flash Point: 155°C
• PSA: 71.84000
• Density: 1.494g/cm³
• LogP: 2.93480
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

3-Chloro-5-nitroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-chloro-5-nitro-aniline

There total 4 articles about 3-chloro-5-nitro-aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-chloro-3,5-dinitrobenzene (618-86-0) → 3-nitro-5-chloroaniline (5344-44-5)

Guidance literature:

With diammonium sulfide; In ethanol; water; for 1h; Heating / reflux;

Reference yield:

3, 5-dinitroaniline (618-87-1) → 3-nitro-5-chloroaniline (5344-44-5)

Guidance literature:

Multi-step reaction with 2 steps

1: Diazotization_.Behandlung der Diazoniumsalz-Loesung mit CuCl in konz. wss. HCl

2: ethanol; aqueous sodium polysulfide

With sodium polysulfide; ethanol;

Reference yield:

meta-dinitrobenzene (99-65-0) → 3-nitro-5-chloroaniline (5344-44-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; trichloroisocyanuric acid / 130 °C

2: ammonium sulfide / ethanol / Reflux

With ammonium sulfide; trichloroisocyanuric acid; sulfuric acid; In ethanol;

DOI:10.1021/acs.jafc.6b00380

upstream raw materials:

1-chloro-3,5-dinitrobenzene

ethanol

hydrogen sulfide

ammonia

Downstream raw materials:

3,5-dichloro-1-nitrobenzene

1-Chloro-3-isothiocyanato-5-nitro-benzene

N-[3,5-dichlorophenyl]thiourea

3,5-Dichloroaniline