2-FURYL-2-THIAZOLYL KETONE

Base Information

• Chemical Name: 2-FURYL-2-THIAZOLYL KETONE
• CAS No.: 112969-91-2
• Molecular Formula: C8H5NO2S
• Molecular Weight: 179.19600
• Mol file: 112969-91-2.mol

Synonyms:Furan-2-yl-thiazol-2-yl-methanone;1,3-Thiazol-2-yl 2-furyl ketone;2-furyl 2-thiazolyl ketone;

Chemical Property of 2-FURYL-2-THIAZOLYL KETONE

Chemical Property:

• PSA: 71.34000
• LogP: 1.96710

Purity/Quality:

99% ^*data from raw suppliers

2-FURYL-2-THIAZOLYLKETONE ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-FURYL-2-THIAZOLYL KETONE

There total 4 articles about 2-FURYL-2-THIAZOLYL KETONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1,3-thiazole (288-47-1) + 2-furancarbonyl chloride (527-69-5) → 1,3-Thiazol-2-yl 2-furyl ketone (112969-91-2)

Guidance literature:

With dmap; triethylamine; In acetonitrile; at 80 ℃; for 24h; Sealed tube; Inert atmosphere;

DOI:10.1055/s-0033-1339858

Reference yield: 82.0%

2-furancarbonyl chloride (527-69-5) + 2-(trimethylsilyl)thiazole (79265-30-8) → 1,3-Thiazol-2-yl 2-furyl ketone (112969-91-2)

Guidance literature:

In dichloromethane; for 20h; Ambient temperature;

DOI:10.1021/jo00243a029

Reference yield: 70.0%

1,3-Thiazol-2-yl(2-furyl)methanol (112970-04-4) → 1,3-Thiazol-2-yl 2-furyl ketone (112969-91-2)

Guidance literature:

With sulfuric acid; oxygen; In 1,2-dimethoxyethane; water; at 80 ℃; for 24h;

upstream raw materials:

2-furancarbonyl chloride

2-(trimethylsilyl)thiazole

1,3-Thiazol-2-yl(2-furyl)methanol

furfural

Refernces

• 1、 D'Auria, Maurizio,Mauriello, Giacomo,Racioppi, Rocco. "An unusual oxidation of thiazol-2-ylmethanol in hydrolytic conditions". . p. 37 - 40. Retrieved 2007/10/03.