1H-Indole-4-methanol, a-(acetyloxy)-1-[(4-methylphenyl)sulfonyl]-, acetate (ester)

Base Information

Chemical Name:1H-Indole-4-methanol, a-(acetyloxy)-1-[(4-methylphenyl)sulfonyl]-, acetate (ester)
CAS No.:112970-66-8
Molecular Formula:C20H19NO6S
Molecular Weight:401.44
Hs Code.:

Synonyms:

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Chemical Property of 1H-Indole-4-methanol, a-(acetyloxy)-1-[(4-methylphenyl)sulfonyl]-, acetate (ester)

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Technology Process of 1H-Indole-4-methanol, a-(acetyloxy)-1-[(4-methylphenyl)sulfonyl]-, acetate (ester)

There total 6 articles about 1H-Indole-4-methanol, a-(acetyloxy)-1-[(4-methylphenyl)sulfonyl]-, acetate (ester) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 112970-53-3
2-vinyl-3-(diacetoxymethyl)-N-tosylaniline

: 112970-66-8
4-(diacetoxymethyl)-N-tosylindole

Guidance literature:: With dichloro bis(acetonitrile) palladium(II); p-benzoquinone; lithium chloride; In N,N-dimethyl-formamide; at 100 - 110 ℃; for 28h;
DOI:10.1021/jo00241a010

Reference yield:

: 570-24-1
2-Methyl-6-nitroaniline

: 112970-66-8
4-(diacetoxymethyl)-N-tosylindole

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) hydrobromic acid, sodium nitrite, 2.) coopper(I) bromide / 1.) water, 1,4-dioxane, 0 deg C, 15 min, 2.) a) 0 deg C, 15 min, b) 60 deg C,15 min

2: 19 percent / concd. sulfuric acid, chromium trioxide / 3 h / 0 - 10 °C

3: 44 percent / iron / ethanol; acetic acid / 3.5 h / Heating

4: 94 percent / pyridine / 6 h / Ambient temperature

5: 86 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / toluene / 36 h / Heating

6: 60 percent / bis(acetonitrile)palladium chloride, p-benzoquinone, lithium chloride / dimethylformamide / 28 h / 100 - 110 °C

With chromium(VI) oxide; dichloro bis(acetonitrile) palladium(II); tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; hydrogen bromide; iron; p-benzoquinone; lithium chloride; copper(I) bromide; sodium nitrite; In pyridine; ethanol; acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00241a010

Reference yield:

: 41085-43-2
2-bromo-3-nitrotoluene

: 112970-66-8
4-(diacetoxymethyl)-N-tosylindole

Guidance literature:: Multi-step reaction with 5 steps

1: 19 percent / concd. sulfuric acid, chromium trioxide / 3 h / 0 - 10 °C

2: 44 percent / iron / ethanol; acetic acid / 3.5 h / Heating

3: 94 percent / pyridine / 6 h / Ambient temperature

4: 86 percent / tetrakis(triphenylphosphine)palladium⁽⁰⁾ / toluene / 36 h / Heating

5: 60 percent / bis(acetonitrile)palladium chloride, p-benzoquinone, lithium chloride / dimethylformamide / 28 h / 100 - 110 °C

With chromium(VI) oxide; dichloro bis(acetonitrile) palladium(II); tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; iron; p-benzoquinone; lithium chloride; In pyridine; ethanol; acetic acid; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00241a010