indomethacin ethoxycarbonylmethyl ester

Base Information

• Chemical Name: indomethacin ethoxycarbonylmethyl ester
• CAS No.: 76812-43-6
• Molecular Formula: C₂₃H₂₂ClNO₆
• Molecular Weight: 443.884
• Mol file: 76812-43-6.mol

Synonyms:Acemetacinethyl ester; Ethoxycarbonylmethyl indomethacin; Indomethacinethoxycarbonylmethyl ester

Chemical Property of indomethacin ethoxycarbonylmethyl ester

Chemical Property:

• Vapor Pressure: 2.13E-11mmHg at 25°C
• Boiling Point: 532°C at 760 mmHg
• Flash Point: 275.5°C
• PSA: 83.83000
• Density: 1.28g/cm³
• LogP: 3.94900

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

Useful:

Technology Process of indomethacin ethoxycarbonylmethyl ester

There total 2 articles about indomethacin ethoxycarbonylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid (53-86-1) + ethyl bromoacetate (105-36-2) → indomethacin ethoxycarbonylmethylester (76812-43-6)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In benzene; at 20 ℃; for 2h;

DOI:10.1111/j.2042-7158.1983.tb02969.x

Reference yield:

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid (53-86-1) → indomethacin ethoxycarbonylmethylester (76812-43-6)

Guidance literature:

With potassium carbonate; Multistep reaction;

upstream raw materials:

[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid

ethyl bromoacetate

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