1(2H)-Pyridinecarboxylic acid, 3-cyclohexyl-, phenyl ester

Base Information

• Chemical Name: 1(2H)-Pyridinecarboxylic acid, 3-cyclohexyl-, phenyl ester
• CAS No.: 113118-71-1
• Molecular Formula: C₁₈H₂₁NO₂
• Molecular Weight: 283.37
• Mol file: 113118-71-1.mol

Synonyms:

Chemical Property of 1(2H)-Pyridinecarboxylic acid, 3-cyclohexyl-, phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1(2H)-Pyridinecarboxylic acid, 3-cyclohexyl-, phenyl ester

There total 3 articles about 1(2H)-Pyridinecarboxylic acid, 3-cyclohexyl-, phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

cyclohexylmagnesiumchloride (931-51-1) + 3-bromo-1-(phenoxycarbonyl)-1,2-dihydropyridine (110619-11-9) → 3-cyclohexyl-1-(phenoxycarbonyl)-1,2-dihydropyridine (113118-71-1)

Guidance literature:

With [1,3-bis(diphenylphosphino)propane]nickel(II) dichloride; In tetrahydrofuran; benzene; for 2h; Ambient temperature;

Reference yield:

3-Bromopyridine (626-55-1,163928-56-1) → 3-cyclohexyl-1-(phenoxycarbonyl)-1,2-dihydropyridine (113118-71-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / NaBH₄ / methanol / -78 °C

2: 55 percent / bis(1,3-diphenylphosphino)propanenickel(II) chloride / benzene; tetrahydrofuran / 2 h / Ambient temperature

With sodium tetrahydroborate; [1,3-bis(diphenylphosphino)propane]nickel(II) dichloride; In tetrahydrofuran; methanol; benzene;

Reference yield:

phenyl chloroformate (1885-14-9) → 3-cyclohexyl-1-(phenoxycarbonyl)-1,2-dihydropyridine (113118-71-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 35 percent / NaBH₄ / methanol / -78 °C

2: 55 percent / bis(1,3-diphenylphosphino)propanenickel(II) chloride / benzene; tetrahydrofuran / 2 h / Ambient temperature

With sodium tetrahydroborate; [1,3-bis(diphenylphosphino)propane]nickel(II) dichloride; In tetrahydrofuran; methanol; benzene;

upstream raw materials:

cyclohexylmagnesiumchloride

3-bromo-1-(phenoxycarbonyl)-1,2-dihydropyridine

3-Bromopyridine

phenyl chloroformate

Downstream raw materials:

5-Cyclohexyl-pyridine-3-carbaldehyde

3-Cyclohexyl-5-formyl-2H-pyridine-1-carboxylic acid phenyl ester

Refernces