Synonyms:2,3-diazabicyclo[5.4.0]undeca-3,5,7,9,11-pentaene; ; 1H-1,2-benzodiazepine
99% *data from raw suppliers
BENZODIAZEPINE 95.00% *data from reagent suppliers
The study focuses on the crystalline properties of benzodiazepines, a class of organic compounds known for their pharmacological properties, including antifungal, antibacterial, analgesic, tranquilizing, and anti-convulsant activities. The research specifically examines the molecular structures of four 1,5-benzodiazepine derivatives, which are 4-(2-hydroxyphenyl)-2-phenyl-2,3-dihydro-1H-1,5-benzodiazepine (I), 2-(2,3-dimethoxyphenyl)-4-(2-hydroxyphenyl)-2,3-dihydro-1H-1,5-benzodiazepine (II), 2-(3,4-dimethoxyphenyl)-4-(2-hydroxyphenyl)-2,3-dihydro-1H-1,5-benzodiazepine (III), and 2-(2,5-dimethoxyphenyl)-4-(2-hydroxyphenyl)-2,3-dihydro-1,5-benzodiazepine (IV). These compounds were selected due to their potential in supramolecular chemistry, where they can form ladder or brick structures through hydrogen-bonding networks. The study aims to understand the influence of intermolecular interactions on the supramolecular packing of these compounds, which is crucial for their performance in various pharmaceutical applications.
The research investigates a new class of compounds that interact with benzodiazepine (BZ) receptors, aiming to develop antianxiety agents without nonspecific central nervous system (CNS) depressant side effects. The study synthesized and tested various 6-(alkylamino)-3-aryl-1,2,4-triazolo[3,4-a]phthalazines for their ability to displace diazepam from rat brain binding sites in vitro and their anticonvulsant and anticonflict properties in vivo. Key chemicals used include diazepam as a reference, [3H]diazepam for radioligand binding assays, and a range of synthesized compounds such as 3-aryl-6-chloro-1,2,4-triazolo[3,4-a]phthalazines and their derivatives. The findings revealed that some compounds, like N~-bis(2-methoxyethyl)-3-(4-methoxyphenyl)-1,2,4-triazolo[3,4-a]phthalazin-6-amine (80), showed significant binding affinity and anticonflict activity without impairing motor coordination at lower doses, suggesting selective anxiolytic activity. The study concludes that these compounds could represent a new class of BZ receptor ligands with potential therapeutic applications, though further research is needed to explore their clinical relevance and species-dependent effects.
The research investigates the reactions of 4-oxo-4H-1-benzopyran-3-carboxaldehydes (3-formylchromones) with 1,2-diamines. The purpose is to explore the potential transformations and products formed from these reactions. Key chemicals used include 3-formylchromones, 1,2-ethanediamine, and o-phenylenediamine. The study found that when 3-formylchromones react with 1,2-ethanediamine, bis-imines precipitate out in high yield, but the intermediate aldimines and diazepines could not be detected. When 3-formylchromones react with o-phenylenediamine, an imine is formed, which upon further refluxing in acetic acid, yields fused benzodiazepines. The research concludes that the stereochemistry of the bis-imines formed is either (E, E) or (Z, Z), and that the imine formed from o-phenylenediamine does not cyclize to benzodiazepine derivatives due to the weak nucleophilicity of the aromatic amino group and poor electrophilicity of the benzylic carbonyl C-atom.
The study focuses on the synthesis, characterization, and evaluation of novel 1,5-benzodiazepine derivatives (compounds 2-7) for their potential applications in corrosion inhibition and antibacterial activities. The chemicals used in the study include 1-ethyl-4-phenyl-1,5-benzodiazepine-2-thione, phosphorus pentasulfide, hydrazine hydrate, carbon disulfide, and various alkylating agents such as propargyl bromide, benzyl chloride, and ethyl bromoacetate. These chemicals served the purpose of synthesizing the target benzodiazepine derivatives through a series of reactions including sulfurization, condensation, and alkylation. The synthesized compounds were then characterized using spectroscopic techniques and single-crystal X-ray crystallography. The study aimed to determine the molecular and crystal structures of these compounds, analyze their intermolecular interactions through Hirshfeld surface analysis, and evaluate their potential as corrosion inhibitors for aluminum, copper, and iron in acidic media using Monte Carlo simulations. Additionally, the antibacterial activity of these compounds against Gram-positive and Gram-negative bacteria was assessed, with the results indicating their potential as antibacterial agents.
The research focused on the synthesis and evaluation of a series of 6-substituted-9-(3-formamidobenzyl)purines for their benzodiazepine receptor (BZR) binding activity. The purpose was to explore the effects of structural changes on BZR binding activity and in vivo Geller-Seifter Conflict activity. The study concluded that while several of these compounds bound to the BZR with potency comparable to benzodiazepines, none exhibited significant in vivo activity in the Geller-Seifter Conflict test, suggesting they may act as antagonists rather than agonists. Key chemicals used in the synthesis process included various amines, alcohols, and nucleophilic reagents for the substitution reactions, as well as reagents like sodium hydroxide, sodium azide, formic acid, and catalytic hydrogenation for specific transformations. The target compounds were derived from 6-chloropurine and 9-(3-formamidobenzyl)-9H-purine, with substitutions at the 6-position leading to a range of structurally diverse purines.
The research involves the synthesis of a series of novel hybrid molecules that combine isoxazoles and benzodiazepines, with a dimethyl bicycloheptyl group added to enhance lipophilicity. The aim was to create compounds that could potentially act on multiple biological targets or enhance each other's activity. Key chemicals used in the synthesis include camphene, acetone, iron (III) nitrate nonahydrate, various aromatic aldehydes, and o-phenylenediamine. The synthesized compounds were characterized using techniques like NMR and IR spectroscopy. The compounds were then screened for their antibacterial and antifungal activities against a range of microbial strains, but none showed promising antimicrobial or antifungal activity up to concentrations of 180 μg/mL.
The research focuses on an efficient and convenient method for synthesizing 1,5-benzothiazepines and benzodiazepines without the use of solvents. The study employs chalcones as starting materials, reacting them with o-amino thiophenol and o-phenylenediamine in the presence of inorganic supports such as silica gel and alumina. These reactions are carried out at 80°C under solvent-free conditions, resulting in the formation of the desired heterocyclic compounds. The synthesized compounds are characterized using elemental analysis, IR, 1H NMR, and 13C NMR spectroscopy. The research also evaluates the antibacterial activity of the synthesized compounds against pathogens like B. subtilis, E. coli, and S. typhi, revealing that some of the compounds exhibit weak to moderate antibacterial activity. The study highlights the advantages of solvent-free conditions over traditional methods, emphasizing the efficiency and environmental benefits of this approach in the synthesis of these important heterocyclic compounds.
Total 8 Pictures about this product
