1H-Indene-5-carboxaldehyde, 1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6-(dimethylphenylsilyl)-2, 3,3a,6,7,7a-hexahydro-2-[(tetrahydro-2H-pyran-2-yl)oxy]-

Base Information

Chemical Name:1H-Indene-5-carboxaldehyde, 1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6-(dimethylphenylsilyl)-2, 3,3a,6,7,7a-hexahydro-2-[(tetrahydro-2H-pyran-2-yl)oxy]-
CAS No.:113208-27-8
Molecular Formula:C₃₀H₄₈O₄Si₂
Molecular Weight:528.88
Hs Code.:

1H-Indene-5-carboxaldehyde,
1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6-(dimethylphenylsilyl)-2,
3,3a,6,7,7a-hexahydro-2-[(tetrahydro-2H-pyran-2-yl)oxy]-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Indene-5-carboxaldehyde, 1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6-(dimethylphenylsilyl)-2, 3,3a,6,7,7a-hexahydro-2-[(tetrahydro-2H-pyran-2-yl)oxy]-

Chemical Property:

Purity/Quality:: 99.90% ^*data from raw suppliers

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Technology Process of 1H-Indene-5-carboxaldehyde, 1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6-(dimethylphenylsilyl)-2, 3,3a,6,7,7a-hexahydro-2-[(tetrahydro-2H-pyran-2-yl)oxy]-

There total 8 articles about 1H-Indene-5-carboxaldehyde, 1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6-(dimethylphenylsilyl)-2, 3,3a,6,7,7a-hexahydro-2-[(tetrahydro-2H-pyran-2-yl)oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 113331-54-7,113428-24-3
(2R,3S,4R)-3-(tert-Butyl-dimethyl-silanyloxymethyl)-2-[2-(dimethyl-phenyl-silanyl)-4-oxo-butyl]-4-(tetrahydro-pyran-2-yloxy)-cyclopentanecarbaldehyde

: 113208-27-8,113331-55-8,113331-56-9
(1S,2R,3aS,7aS)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-6-(dimethyl-phenyl-silanyl)-2-(tetrahydro-pyran-2-yloxy)-2,3,3a,6,7,7a-hexahydro-1H-indene-5-carbaldehyde

Guidance literature:: With dibenzylammonium trifluoroacetate salt; In toluene; at 110 ℃; Yield given;
DOI:10.1016/S0040-4039(00)96003-9

Reference yield:

: 65025-95-8
(3aR,4S,5R,6aS)-4-({[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl)-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-one

: 113208-27-8,113331-55-8,113331-56-9
(1S,2R,3aS,7aS)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-6-(dimethyl-phenyl-silanyl)-2-(tetrahydro-pyran-2-yloxy)-2,3,3a,6,7,7a-hexahydro-1H-indene-5-carbaldehyde

Guidance literature:: Multi-step reaction with 8 steps

1: DIBAH / toluene / -78 °C

2: toluene / 60 °C

3: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C

4: Zn, TiCl₄ / Ambient temperature

5: 1.)Siam₂BH, 2.) 30percent H₂O₂, 6N NaOH / 1.) THF, 0 deg C, 2.) THF, 0 deg C

6: 98 percent / LiAlH₄ / tetrahydrofuran / 0 °C

7: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C

8: dibenzylammonium trifluoroacetate / toluene / 110 °C

With sodium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; dihydrogen peroxide; bis-(1,2-dimethylpropyl)borane; titanium tetrachloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; zinc; dibenzylammonium trifluoroacetate salt; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4039(00)96003-9

Reference yield:

: 123536-33-4
(E)-4-[(1R,2S,3R,5S)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-hydroxy-3-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-but-2-enoic acid methyl ester

: 113208-27-8,113331-55-8,113331-56-9
(1S,2R,3aS,7aS)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-6-(dimethyl-phenyl-silanyl)-2-(tetrahydro-pyran-2-yloxy)-2,3,3a,6,7,7a-hexahydro-1H-indene-5-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C

2: Zn, TiCl₄ / Ambient temperature

3: 1.)Siam₂BH, 2.) 30percent H₂O₂, 6N NaOH / 1.) THF, 0 deg C, 2.) THF, 0 deg C

4: 98 percent / LiAlH₄ / tetrahydrofuran / 0 °C

5: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C

6: dibenzylammonium trifluoroacetate / toluene / 110 °C

With sodium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; dihydrogen peroxide; bis-(1,2-dimethylpropyl)borane; titanium tetrachloride; dimethyl sulfoxide; triethylamine; zinc; dibenzylammonium trifluoroacetate salt; In tetrahydrofuran; toluene;
DOI:10.1016/S0040-4039(00)96003-9