N-2,3-dihydro-1,4-benzodioxin-6-yl-2-(ethylamino)acetamide hydrochloride

Base Information

• Chemical Name: N-2,3-dihydro-1,4-benzodioxin-6-yl-2-(ethylamino)acetamide hydrochloride
• CAS No.: 100254-21-5
• Molecular Formula: C₁₂H₁₆N₂O₃
• Molecular Weight: 236.271
• Hs Code.: 2932999099
• DSSTox Substance ID: DTXSID50656379
• Mol file: 100254-21-5.mol

Synonyms:100254-21-5;N-2,3-dihydro-1,4-benzodioxin-6-yl-2-(ethylamino)acetamide hydrochloride;N-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-2-(ethylamino)acetamide hydrochloride;N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(ethylamino)acetamide hydrochloride;N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-(ethylamino)acetamide;hydrochloride;DTXSID50656379;PTMMYHGFROTKLS-UHFFFAOYSA-N;AKOS008012851;EN300-07310;A910147;N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-N~2~-ethylglycinamide--hydrogen chloride (1/1);1172402-50-4

Chemical Property of N-2,3-dihydro-1,4-benzodioxin-6-yl-2-(ethylamino)acetamide hydrochloride

Chemical Property:

• Vapor Pressure: 3.31E-07mmHg at 25°C
• Boiling Point: 418.3°Cat760mmHg
• Flash Point: 206.8°C
• PSA: 59.59000
• Density: 1.222g/cm³
• LogP: 2.27170
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 272.0927701
• Heavy Atom Count: 18
• Complexity: 260

Purity/Quality:

95% ^*data from raw suppliers

N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-(ethylamino)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCNCC(=O)NC1=CC2=C(C=C1)OCCO2.Cl

Technology Process of N-2,3-dihydro-1,4-benzodioxin-6-yl-2-(ethylamino)acetamide hydrochloride

There total 3 articles about N-2,3-dihydro-1,4-benzodioxin-6-yl-2-(ethylamino)acetamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-nitro-2,3-dihydrobenzo[b][1,4]dioxine (16498-20-7) → N-ethyl-glycine-(2,3-dihydro-benzo[1,4]dioxin-6-ylamide) (100254-21-5)

Guidance literature:

Multi-step reaction with 3 steps

1: palladium; ethanol / Hydrogenation

2: acetone

With ethanol; palladium; acetone;

Reference yield:

6-amino-3,4-benzodioxane (22013-33-8) → N-ethyl-glycine-(2,3-dihydro-benzo[1,4]dioxin-6-ylamide) (100254-21-5)

Guidance literature:

Multi-step reaction with 2 steps

1: acetone

With acetone;

Reference yield:

2-chloro-N-(2,3-dihydrobenzo[β][1,4]dioxin-6-yl)acetamide (42477-07-6) + ethylamine (75-04-7,85404-22-4) → N-ethyl-glycine-(2,3-dihydro-benzo[1,4]dioxin-6-ylamide) (100254-21-5)

Guidance literature:

upstream raw materials:

2-chloro-N-(2,3-dihydrobenzo[β][1,4]dioxin-6-yl)acetamide

ethylamine

6-nitro-2,3-dihydrobenzo[b][1,4]dioxine

6-amino-3,4-benzodioxane