[5-[(Piperidin-1-yl)carbonyl]-1H-benzimidazol-2-yl]carbamic acid methyl ester

Base Information

• Chemical Name: [5-[(Piperidin-1-yl)carbonyl]-1H-benzimidazol-2-yl]carbamic acid methyl ester
• CAS No.: 65003-32-9
• Molecular Formula: C₁₅H₁₈N₄O₃
• Molecular Weight: 302.333
• Hs Code.: 2933990090
• Mol file: 65003-32-9.mol

Synonyms:[5-(piperidine-1-carbonyl)-1(3)H-benzoimidazol-2-yl]-carbamic acid methyl ester;Methyl (5-(1-piperidinylcarbonyl)-1H-benzimidazol-2-yl)carbamate;Methyl 5(6)-piperidinocarbonylbenzimidazole-2-carbamate;Carbamic acid,(5-(1-piperidinylcarbonyl)-1H-benzimidazol-2-yl)-,methyl ester;methyl [5-(piperidin-1-ylcarbonyl)-1H-benzimidazol-2-yl]carbamate;

Chemical Property of [5-[(Piperidin-1-yl)carbonyl]-1H-benzimidazol-2-yl]carbamic acid methyl ester

Chemical Property:

• PSA: 90.81000
• Density: 1.376g/cm³
• LogP: 2.31880

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [5-[(Piperidin-1-yl)carbonyl]-1H-benzimidazol-2-yl]carbamic acid methyl ester

There total 8 articles about [5-[(Piperidin-1-yl)carbonyl]-1H-benzimidazol-2-yl]carbamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-nitro-4-acetamidobenzoic acid (1539-06-6) → methyl [5-(piperidin-1-ylcarbonyl)-1H-benzimidazol-2-yl]carbamate (65003-32-9)

Guidance literature:

Multi-step reaction with 5 steps

1: SOCl₂ / benzene / 4 h / Heating

2: Et₃N / benzene / 2 h / Ambient temperature

3: 70 percent / 10percent aq. NaOH / ethanol / 1 h / Ambient temperature

4: hydrazine hydrate / Raney Ni / ethanol / 1 h / Heating

5: 25percent aq. NaOH, AcOH / ethanol / 1 h

With sodium hydroxide; thionyl chloride; hydrazine hydrate; acetic acid; triethylamine; nickel; In ethanol; benzene;

DOI:10.1021/jm00374a025

Reference yield:

2'-Nitro-4'-piperidinocarbamoylacetanilid (89790-64-7) → methyl [5-(piperidin-1-ylcarbonyl)-1H-benzimidazol-2-yl]carbamate (65003-32-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / 10percent aq. NaOH / ethanol / 1 h / Ambient temperature

2: hydrazine hydrate / Raney Ni / ethanol / 1 h / Heating

3: 25percent aq. NaOH, AcOH / ethanol / 1 h

With sodium hydroxide; hydrazine hydrate; acetic acid; nickel; In ethanol;

DOI:10.1021/jm00374a025

Reference yield:

3-nitro-4-acetylaminobenzoyl chloride (24170-23-8) → methyl [5-(piperidin-1-ylcarbonyl)-1H-benzimidazol-2-yl]carbamate (65003-32-9)

Guidance literature:

Multi-step reaction with 4 steps

1: Et₃N / benzene / 2 h / Ambient temperature

2: 70 percent / 10percent aq. NaOH / ethanol / 1 h / Ambient temperature

3: hydrazine hydrate / Raney Ni / ethanol / 1 h / Heating

4: 25percent aq. NaOH, AcOH / ethanol / 1 h

With sodium hydroxide; hydrazine hydrate; acetic acid; triethylamine; nickel; In ethanol; benzene;

DOI:10.1021/jm00374a025

upstream raw materials:

S-Methylisothiourea sulfate

methyl chloroformate

(3,4-diaminophenyl)(piperidin-1-yl)methanone

3-nitro-4-acetamidobenzoic acid