2H-1,4-Benzodiazepin-2-one, 5-(2-fluorophenyl)-1,3-dihydro-7-iodo-

Base Information

Chemical Name:2H-1,4-Benzodiazepin-2-one, 5-(2-fluorophenyl)-1,3-dihydro-7-iodo-
CAS No.:30843-56-2
Molecular Formula:C15H10 F I N2 O
Molecular Weight:380.16
Hs Code.:
DSSTox Substance ID:DTXSID80184857
Wikidata:Q83055795
Mol file:30843-56-2.mol

Synonyms:Ro 7-9749

Suppliers and Price of 2H-1,4-Benzodiazepin-2-one, 5-(2-fluorophenyl)-1,3-dihydro-7-iodo-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 2H-1,4-Benzodiazepin-2-one, 5-(2-fluorophenyl)-1,3-dihydro-7-iodo-

Chemical Property:

Vapor Pressure:1.77E-09mmHg at 25°C
Boiling Point:482.8°Cat760mmHg
Flash Point:245.8°C
Density:1.76g/cm³
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:379.98219
Heavy Atom Count:20
Complexity:415

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(=O)NC2=C(C=C(C=C2)I)C(=N1)C3=CC=CC=C3F

Technology Process of 2H-1,4-Benzodiazepin-2-one, 5-(2-fluorophenyl)-1,3-dihydro-7-iodo-

There total 4 articles about 2H-1,4-Benzodiazepin-2-one, 5-(2-fluorophenyl)-1,3-dihydro-7-iodo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-Amino-N-[2-(2-fluoro-benzoyl)-4-iodo-phenyl]-acetamide

: 30843-56-2
5-(2-fluorophenyl)-1,3-dihydro-7-iodo-2H-1,4-benzodiazepin-2-one

Guidance literature:: With acetic acid; In ethanol; for 0.5h; Heating;
DOI:10.1021/jm00107a048

Reference yield:

: 30843-54-0
(2-amino-5-iodophenyl)(2-fluorophenyl)methanone

: 30843-56-2
5-(2-fluorophenyl)-1,3-dihydro-7-iodo-2H-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 10percent aq. Na₂CO₃ / CH₂Cl₂ / 0.5 h / 0 °C

2: liquid ammonia / CH₂Cl₂ / 16 h / Heating

3: HOAc / ethanol / 0.5 h / Heating

With ammonia; sodium carbonate; acetic acid; In ethanol; dichloromethane;
DOI:10.1021/jm00107a048

Reference yield:

: 30843-55-1
2-Brom-2'-(2-fluorbenzoyl)-4'-jodacetanilid

: 30843-56-2
5-(2-fluorophenyl)-1,3-dihydro-7-iodo-2H-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: liquid ammonia / CH₂Cl₂ / 16 h / Heating

2: HOAc / ethanol / 0.5 h / Heating

With ammonia; acetic acid; In ethanol; dichloromethane;
DOI:10.1021/jm00107a048