1,3-Benzodioxole-5-acetic acid, 7-methoxy-4-(1-oxopropoxy)-6-(phenylmethyl)-, methyl ester

Base Information

Chemical Name:1,3-Benzodioxole-5-acetic acid, 7-methoxy-4-(1-oxopropoxy)-6-(phenylmethyl)-, methyl ester
CAS No.:113326-53-7
Molecular Formula:C21H22O7
Molecular Weight:386.401
Hs Code.:
Mol file:113326-53-7.mol

Synonyms:

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Chemical Property of 1,3-Benzodioxole-5-acetic acid, 7-methoxy-4-(1-oxopropoxy)-6-(phenylmethyl)-, methyl ester

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Technology Process of 1,3-Benzodioxole-5-acetic acid, 7-methoxy-4-(1-oxopropoxy)-6-(phenylmethyl)-, methyl ester

There total 10 articles about 1,3-Benzodioxole-5-acetic acid, 7-methoxy-4-(1-oxopropoxy)-6-(phenylmethyl)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 802294-64-0,79-09-4
propionic acid

: 113326-51-5
methyl 4-benzyloxy-7-methoxy-1,3-benzodioxol-5-ylacetate

: 113326-52-6
methyl 7-methoxy-4-propionyloxy-1,3-benzodioxol-5-ylacetate

: 113326-53-7
methyl 6-benzyl-7-methoxy-4-propionyloxy-1,3-benzodioxol-5-ylacetate

Guidance literature:: With trifluoroacetic anhydride; for 2.5h; Ambient temperature;

Reference yield:

: 23731-75-1
1,4-dimethoxy-2,3-methylenedioxybenzene

: 113326-53-7
methyl 6-benzyl-7-methoxy-4-propionyloxy-1,3-benzodioxol-5-ylacetate

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / POCl₃ / 48 h / Ambient temperature

2: 70 percent / BCl₃ / CH₂Cl₂ / 0.25 h / Ambient temperature

3: 93 percent / K₂CO₃ / dimethylformamide / 3 h / 75 °C

4: 60 percent / Triton B / tetrahydrofuran / 4 h / Heating

5: 1.) HCl; 2.) W-2 Raney nickel / 1.) MeOH, -5 deg C, 5 min; 2.) MeOH, reflux, 1 h

6: 54 percent / trifluoroacetic anhydride / 2.5 h / Ambient temperature

With hydrogenchloride; W-2 Raney nickel; boron trichloride; N-benzyl-trimethylammonium hydroxide; potassium carbonate; trifluoroacetic anhydride; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 21450-56-6
1,2,3,4-tetramethoxybenzene

: 113326-53-7
methyl 6-benzyl-7-methoxy-4-propionyloxy-1,3-benzodioxol-5-ylacetate

Guidance literature:: Multi-step reaction with 8 steps

1: 80 percent / BCl₃ / CH₂Cl₂ / 5 h / Ambient temperature

2: 52 percent / CsF / dimethylformamide / 6 h / 120 °C

3: 87 percent / POCl₃ / 48 h / Ambient temperature

4: 70 percent / BCl₃ / CH₂Cl₂ / 0.25 h / Ambient temperature

5: 93 percent / K₂CO₃ / dimethylformamide / 3 h / 75 °C

6: 60 percent / Triton B / tetrahydrofuran / 4 h / Heating

7: 1.) HCl; 2.) W-2 Raney nickel / 1.) MeOH, -5 deg C, 5 min; 2.) MeOH, reflux, 1 h

8: 54 percent / trifluoroacetic anhydride / 2.5 h / Ambient temperature

With hydrogenchloride; W-2 Raney nickel; boron trichloride; N-benzyl-trimethylammonium hydroxide; potassium carbonate; cesium fluoride; trifluoroacetic anhydride; trichlorophosphate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;