1,3-Benzodioxole-5-acetic acid, 4-hydroxy-7-methoxy-6-(phenylmethyl)-, methyl ester

Base Information

Chemical Name:1,3-Benzodioxole-5-acetic acid, 4-hydroxy-7-methoxy-6-(phenylmethyl)-, methyl ester
CAS No.:113326-54-8
Molecular Formula:C18H18O6
Molecular Weight:330.337
Hs Code.:
Mol file:113326-54-8.mol

Synonyms:

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Chemical Property of 1,3-Benzodioxole-5-acetic acid, 4-hydroxy-7-methoxy-6-(phenylmethyl)-, methyl ester

Chemical Property:

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Technology Process of 1,3-Benzodioxole-5-acetic acid, 4-hydroxy-7-methoxy-6-(phenylmethyl)-, methyl ester

There total 11 articles about 1,3-Benzodioxole-5-acetic acid, 4-hydroxy-7-methoxy-6-(phenylmethyl)-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 113326-53-7
methyl 6-benzyl-7-methoxy-4-propionyloxy-1,3-benzodioxol-5-ylacetate

: 113326-54-8
methyl 6-benzyl-4-hydroxy-7-methoxy-1,3-benzodioxol-5-ylacetate

Guidance literature:: With sodium methylate; In methanol; for 1h;

Reference yield:

: 23731-75-1
1,4-dimethoxy-2,3-methylenedioxybenzene

: 113326-54-8
methyl 6-benzyl-4-hydroxy-7-methoxy-1,3-benzodioxol-5-ylacetate

Guidance literature:: Multi-step reaction with 7 steps

1: 87 percent / POCl₃ / 48 h / Ambient temperature

2: 70 percent / BCl₃ / CH₂Cl₂ / 0.25 h / Ambient temperature

3: 93 percent / K₂CO₃ / dimethylformamide / 3 h / 75 °C

4: 60 percent / Triton B / tetrahydrofuran / 4 h / Heating

5: 1.) HCl; 2.) W-2 Raney nickel / 1.) MeOH, -5 deg C, 5 min; 2.) MeOH, reflux, 1 h

6: 54 percent / trifluoroacetic anhydride / 2.5 h / Ambient temperature

7: 89 percent / MeONa / methanol / 1 h

With hydrogenchloride; W-2 Raney nickel; sodium methylate; boron trichloride; N-benzyl-trimethylammonium hydroxide; potassium carbonate; trifluoroacetic anhydride; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 21450-56-6
1,2,3,4-tetramethoxybenzene

: 113326-54-8
methyl 6-benzyl-4-hydroxy-7-methoxy-1,3-benzodioxol-5-ylacetate

Guidance literature:: Multi-step reaction with 9 steps

1: 80 percent / BCl₃ / CH₂Cl₂ / 5 h / Ambient temperature

2: 52 percent / CsF / dimethylformamide / 6 h / 120 °C

3: 87 percent / POCl₃ / 48 h / Ambient temperature

4: 70 percent / BCl₃ / CH₂Cl₂ / 0.25 h / Ambient temperature

5: 93 percent / K₂CO₃ / dimethylformamide / 3 h / 75 °C

6: 60 percent / Triton B / tetrahydrofuran / 4 h / Heating

7: 1.) HCl; 2.) W-2 Raney nickel / 1.) MeOH, -5 deg C, 5 min; 2.) MeOH, reflux, 1 h

8: 54 percent / trifluoroacetic anhydride / 2.5 h / Ambient temperature

9: 89 percent / MeONa / methanol / 1 h

With hydrogenchloride; W-2 Raney nickel; sodium methylate; boron trichloride; N-benzyl-trimethylammonium hydroxide; potassium carbonate; cesium fluoride; trifluoroacetic anhydride; trichlorophosphate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;