1H-Indene-5-pentanoic acid, 1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6-(dimethylphenylsilyl)-2, 3,3a,6,7,7a-hexahydro-2-[(tetrahydro-2H-pyran-2-yl)oxy]-, methyl ester

Base Information

Chemical Name:1H-Indene-5-pentanoic acid, 1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6-(dimethylphenylsilyl)-2, 3,3a,6,7,7a-hexahydro-2-[(tetrahydro-2H-pyran-2-yl)oxy]-, methyl ester
CAS No.:113331-68-3
Molecular Formula:C35H58O5Si2
Molecular Weight:615.014
Hs Code.:
Mol file:113331-68-3.mol

1H-Indene-5-pentanoic acid,
1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6-(dimethylphenylsilyl)-2,
3,3a,6,7,7a-hexahydro-2-[(tetrahydro-2H-pyran-2-yl)oxy]-, methyl ester

Synonyms:

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Chemical Property of 1H-Indene-5-pentanoic acid, 1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6-(dimethylphenylsilyl)-2, 3,3a,6,7,7a-hexahydro-2-[(tetrahydro-2H-pyran-2-yl)oxy]-, methyl ester

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Technology Process of 1H-Indene-5-pentanoic acid, 1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6-(dimethylphenylsilyl)-2, 3,3a,6,7,7a-hexahydro-2-[(tetrahydro-2H-pyran-2-yl)oxy]-, methyl ester

There total 9 articles about 1H-Indene-5-pentanoic acid, 1-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6-(dimethylphenylsilyl)-2, 3,3a,6,7,7a-hexahydro-2-[(tetrahydro-2H-pyran-2-yl)oxy]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 113208-28-9,113331-57-0,113331-58-1,114290-01-6,114290-02-7
(Z)-5-[(1S,2R,3aS,7aS)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-6-(dimethyl-phenyl-silanyl)-2-(tetrahydro-pyran-2-yloxy)-2,3,3a,6,7,7a-hexahydro-1H-inden-5-yl]-pent-4-enoic acid methyl ester

: 113331-69-4
5-[(1S,2R,3aS,7aS)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-6-(dimethyl-phenyl-silanyl)-2-(tetrahydro-pyran-2-yloxy)-octahydro-inden-5-yl]-pentanoic acid methyl ester

: 113331-68-3
5-[(1S,2R,3aS,7aS)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-6-(dimethyl-phenyl-silanyl)-2-(tetrahydro-pyran-2-yloxy)-2,3,3a,6,7,7a-hexahydro-1H-inden-5-yl]-pentanoic acid methyl ester

: 113208-29-0,113331-59-2,113331-60-5
5-[(1S,2R,3aS,7aS)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-6-(dimethyl-phenyl-silanyl)-2-(tetrahydro-pyran-2-yloxy)-octahydro-inden-(5E)-ylidene]-pentanoic acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 25 ℃; under 760 Torr;
DOI:10.1016/S0040-4039(00)96003-9

Reference yield:

: 65025-95-8
(3aR,4S,5R,6aS)-4-({[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl)-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-one

: 113331-68-3
5-[(1S,2R,3aS,7aS)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-6-(dimethyl-phenyl-silanyl)-2-(tetrahydro-pyran-2-yloxy)-2,3,3a,6,7,7a-hexahydro-1H-inden-5-yl]-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 11 steps

1: DIBAH / toluene / -78 °C

2: toluene / 60 °C

3: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C

4: Zn, TiCl₄ / Ambient temperature

5: 1.)Siam₂BH, 2.) 30percent H₂O₂, 6N NaOH / 1.) THF, 0 deg C, 2.) THF, 0 deg C

6: 98 percent / LiAlH₄ / tetrahydrofuran / 0 °C

7: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C

8: dibenzylammonium trifluoroacetate / toluene / 110 °C

9: 1.) t-BuOK / THF, RT

10: diethyl ether / 0 °C

11: 60 percent / H₂ / 10percent Pd-C / methanol / 25 °C / 760 Torr

With sodium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; potassium tert-butylate; hydrogen; dihydrogen peroxide; bis-(1,2-dimethylpropyl)borane; titanium tetrachloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; zinc; dibenzylammonium trifluoroacetate salt; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; toluene;
DOI:10.1016/S0040-4039(00)96003-9

Reference yield:

: 113428-17-4
(E)-4-[(1R,2S,3R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-5-methylene-3-(tetrahydro-pyran-2-yloxy)-cyclopentyl]-but-2-enoic acid methyl ester

: 113331-68-3
5-[(1S,2R,3aS,7aS)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-6-(dimethyl-phenyl-silanyl)-2-(tetrahydro-pyran-2-yloxy)-2,3,3a,6,7,7a-hexahydro-1H-inden-5-yl]-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1.)Siam₂BH, 2.) 30percent H₂O₂, 6N NaOH / 1.) THF, 0 deg C, 2.) THF, 0 deg C

2: 98 percent / LiAlH₄ / tetrahydrofuran / 0 °C

3: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C

4: dibenzylammonium trifluoroacetate / toluene / 110 °C

5: 1.) t-BuOK / THF, RT

6: diethyl ether / 0 °C

7: 60 percent / H₂ / 10percent Pd-C / methanol / 25 °C / 760 Torr

With sodium hydroxide; lithium aluminium tetrahydride; oxalyl dichloride; potassium tert-butylate; hydrogen; dihydrogen peroxide; bis-(1,2-dimethylpropyl)borane; dimethyl sulfoxide; triethylamine; dibenzylammonium trifluoroacetate salt; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; toluene;
DOI:10.1016/S0040-4039(00)96003-9