CYCLOPROPYL 3-THIENYL KETONE

Base Information

• Chemical Name: CYCLOPROPYL 3-THIENYL KETONE
• CAS No.: 113348-25-7
• Molecular Formula: C8H8OS
• Molecular Weight: 152.21400
• Hs Code.: 2934999090
• Mol file: 113348-25-7.mol

Synonyms:Methanone,cyclopropyl-3-thienyl;

Chemical Property of CYCLOPROPYL 3-THIENYL KETONE

Chemical Property:

• Vapor Pressure: 0.0303mmHg at 25°C
• Boiling Point: 244.5oC at 760 mmHg
• Flash Point: 101.6oC
• PSA: 45.31000
• Density: 1.271g/cm3
• LogP: 2.34080

Purity/Quality:

97% ^*data from raw suppliers

Cyclopropyl3-thienylketone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CYCLOPROPYL 3-THIENYL KETONE

There total 2 articles about CYCLOPROPYL 3-THIENYL KETONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

3-thienyl lithium (1192-06-9) + cyclopropropanecarbonitrile (5500-21-0) → cyclopropyl(thiophen-3-yl)methanone (113348-25-7)

Guidance literature:

In diethyl ether; hexane; at -70 ℃; for 1.5h;

Reference yield:

thiophene (188290-36-0,8014-23-1,25233-34-5) + cyclopropropanecarbonitrile (5500-21-0) → cyclopropyl(thiophen-3-yl)methanone (113348-25-7)

Guidance literature:

thiophene; With n-butyllithium; In diethyl ether; hexane; at -78 ℃; for 0.5h;

cyclopropropanecarbonitrile; In diethyl ether; hexane; at -78 - 20 ℃;

With hydrogenchloride; water; In diethyl ether; hexane;

Reference yield:

cyclopropyl(thiophen-3-yl)methanone (113348-25-7) → N-(cyclopropyl(thiophen-3-yl)methyl)-3-(3-sulfamoylphenyl)-1H-indazole-5-carboxamide (1338794-44-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: ammonium acetate / methanol / 0.17 h / 25 °C

1.2: 16 h / 60 °C

2.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0 - 20 °C

With ammonium acetate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2014.06.027

upstream raw materials:

3-thienyl lithium

cyclopropropanecarbonitrile

thiophene

Downstream raw materials:

N-(cyclopropyl(thiophen-3-yl)methyl)-3-(3-sulfamoylphenyl)-1H-indazole-5-carboxamide

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