5500-21-0

Basic information

• Product Name: Cyclopropanecarbonitrile
• Synonyms: Cyclopropanecarboxylic acid nitrile;Cyclopropanenitrile;CYCLOPROPANECARBONITRILE;CYCLOPROPANE CYANIDE;CYCLOPROPYL CYANIDE;CYCLOPROPYLNITRILE;CYANOCYCLOPROPANE;Cyclopropanecarbonitrile,98%
• CAS NO: 5500-21-0
• Molecular Formula: C₄H₅N
• Molecular Weight: 67.09
• EINECS: 226-836-8
• Product Categories: Pharmaceutical Intermediates;Cyclopropanes;Simple 3-Membered Ring Compounds;Impurities, Miscellaneous Reagents
• Mol File: 5500-21-0.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 135 °C(lit.)
• Flash Point: 91 °F
• Appearance: Clear colorless to faintly yellow/Liquid
• Density: 0.911 g/mL at 25 °C(lit.)
• Vapor Pressure: 7.88mmHg at 25°C
• Refractive Index: n20/D 1.421(lit.)
• Storage Temp.: Flammables area
• Solubility: Chloroform, Methanol (Slightly)
• Water Solubility: Miscible with water.
• BRN: 635790
• CAS DataBase Reference: Cyclopropanecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclopropanecarbonitrile(5500-21-0)
• EPA Substance Registry System: Cyclopropanecarbonitrile(5500-21-0)

Safety Data

• Hazard Codes: T,F
• Statements: 10-23/24/25-36/37/38
• Safety Statements: 23-26-36/37-45-36/37/39-16-7/9
• RIDADR: UN 3275 6.1/PG 2
• WGK Germany: 2
• TSCA: Yes
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 5500-21-0(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless to faintly yellow liquid

Uses

Different sources of media describe the Uses of 5500-21-0 differently. You can refer to the following data:
1. Cyclopropanecarbonitrile is a cyano substituted cycloalkane. Cyclopropanecarbonitrile is an Impurity of pazufloxacin mesylate (P211000).
2. Cyclopropanecarbonitrile is used to prepare cis and trans crotonitrile and allyl cyanide. Further, it reacts with phenylmagnesium bromide to give cyclopropyl-phenyl ketone-imine.

InChI:InChI=1/C4H5N/c5-3-4-1-2-4/h4H,1-2H2

Synthetic route

4-Chlorobutyronitrile (628-20-6) → cyclopropropanecarbonitrile (5500-21-0)

Conditions	Yield
With hydrogenchloride; sodium hydroxide; sodium chloride In water; dimethyl sulfoxide	98%
With sodium hydride In ethylene glycol; mineral oil at 20 - 80℃; for 0.5h; Solvent; Reagent/catalyst;	97.2%
With potassium tert-butylate In tetrahydrofuran at -30℃; for 0.333333h;	89%

4-bromobutanenitrile (5332-06-9) → cyclopropropanecarbonitrile (5500-21-0)

Conditions	Yield
With sodium In ethylene glycol at 20 - 50℃; for 0.25h; Temperature; Solvent; Reagent/catalyst;	98%
With ammonia; sodium amide; ferric nitrate
With tetra(n-butyl)ammonium hydroxide In xylene at 40℃;

4-iodobutyronitrile (6727-73-7) → cyclopropropanecarbonitrile (5500-21-0)

Conditions	Yield
With sodium hydride In ethylene glycol; mineral oil at 20 - 40℃; for 0.166667h; Solvent; Reagent/catalyst;	96.5%

cyclopropyl isocyanide (58644-53-4) → cyclopropropanecarbonitrile (5500-21-0)

Conditions	Yield
at 520 - 550℃; under 0.01 Torr;	92%
With 1,1-Diphenylethylene In various solvent(s) at 210℃; Rate constant; Thermodynamic data; ΔG(excit.) <250 deg C>; ΔH(excit.), ΔS(excit.);	98 % Chromat.

acrylonitrile (107-13-1) + 1,1-dibromomethane (74-95-3) → cyclopropropanecarbonitrile (5500-21-0)

Conditions	Yield
With sodium iodide; nickel dibromide; zinc In tetrahydrofuran at 0℃; for 42h;	92%

Cyclopropancarbamid (6228-73-5) → cyclopropropanecarbonitrile (5500-21-0)

Conditions	Yield
With thionyl chloride In toluene for 8h; Reflux;	91%
With trichloromethyl chloroformate In various solvent(s) 0-5 deg C then heated to 60 deg C, 5 min;	86%
With phosphorus pentoxide at 235℃; for 1h; Temperature;

2,4-dichlorobutanenitrile (77100-86-8) → cyclopropropanecarbonitrile (5500-21-0)

Conditions	Yield
With tetraethylammonium tosylate In dimethyl sulfoxide for 10h; electrolysis;	83%

4-bromobutanenitrile (5332-06-9) → 4-hydroxy-1-butanitrile (628-22-8) + cyclopropropanecarbonitrile (5500-21-0)

Conditions	Yield
With oxygen; tetraethylammonium perchlorate In N,N-dimethyl-formamide at 20℃; electroreduction at -1.1 V;	A 10% B 67%

4-Chlorobutyronitrile (628-20-6) + benzaldehyde (100-52-7) → cyclopropropanecarbonitrile (5500-21-0) + trans-2-Phenyltetrahydrofuran-3-carbonitrile + cis-2-Phenyltetrahydrofuran-3-carbonitrile

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran at -30℃; for 0.333333h; Title compound not separated from byproducts;	A 21% B n/a C n/a
With potassium tert-butylate In tetrahydrofuran at -30℃; Product distribution; Further Variations:; Reagents; Temperatures;	A 11% B n/a C n/a

4-Chlorobutyronitrile (628-20-6) + 4-chlorobenzaldehyde (104-88-1) → cyclopropropanecarbonitrile (5500-21-0) + trans-2-(4-Chlorophenyl)tetrahydrofuran-3-carbonitrile + cis-2-(4-Chlorophenyl)tetrahydrofuran-3-carbonitrile

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran at -30℃; for 0.333333h; Title compound not separated from byproducts;	A 16% B n/a C n/a

4-Chlorobutyronitrile (628-20-6) + 3-phenyl-propenal (104-55-2) → cyclopropropanecarbonitrile (5500-21-0) + cis-2-[(E)-2-Phenylethenyl]tetrahydrofuran-3-carbonitrile + trans-2-[(E)-2-Phenylethenyl]tetrahydrofuran-3-carbonitrile

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran at -30℃; for 0.333333h; Title compound not separated from byproducts;	A 15% B n/a C n/a

4-Chlorobutyronitrile (628-20-6) + 3-phenyl-propenal (104-55-2) → (2R,3S)-2-((E)-Styryl)-tetrahydro-furan-3-carbonitrile + (2R,3R)-2-((E)-Styryl)-tetrahydro-furan-3-carbonitrile + cyclopropropanecarbonitrile (5500-21-0)

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran at -30℃;	A n/a B n/a C 15%

4-Chlorobutyronitrile (628-20-6) + 4-methyl-benzaldehyde (104-87-0) → cyclopropropanecarbonitrile (5500-21-0) + trans-2-(4-Methylphenyl)tetrahydrofuran-3-carbonitrile + cis-2-(4-Methylphenyl)tetrahydrofuran-3-carbonitrile

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran at -30℃; for 0.333333h; Title compound not separated from byproducts;	A 14% B n/a C n/a
With potassium tert-butylate In tetrahydrofuran at -30℃;	A 14% B n/a C n/a

4-Chlorobutyronitrile (628-20-6) + sodium ethanolate (141-52-6) → 4-ethoxy-butyronitrile (33563-82-5) + Cyclopropancarbamid (6228-73-5) + cyclopropropanecarbonitrile (5500-21-0)

4-bromobutanenitrile (5332-06-9) → cyclopropanecarboxamidine; cyclopropanecarboxamidine hydrobromide (23662-46-6) + cyclopropropanecarbonitrile (5500-21-0)

Conditions	Yield
With ammonia; sodium amide; ferric nitrate

cyclopropyl trifluoromethanesulfonate (25354-42-1) + tributylhexadecylphosphonium cyanide (66997-38-4) → cyclopropropanecarbonitrile (5500-21-0)

Conditions	Yield
In Cyclopentane 1) 22 h, 50 deg C, 2) 14 h, 70 deg C;	98.8 % Turnov.

2-aminobutanenitrile hydrochloride (93554-80-4) → 2-hydroxybutanenitrile (4476-02-2) + 3-hydroxybutanenitrile (4368-06-3) + (Z)-2-butenenitrile (1190-76-7) + crotononitrile (4786-20-3) + cyclopropropanecarbonitrile (5500-21-0) + syn-2-(Hydroxyimino)butannitril

Conditions	Yield
With perchloric acid; sodium nitrite for 24h; Product distribution; Mechanism; Ambient temperature; pH 3.5 or 1.4, also in HOAc/NaOAc, also (R)-2-aminobutanenitrile*HCl as substrate;	A 48.6 % Chromat. B 4.7 % Chromat. C 14.2 % Chromat. D 12.7 % Chromat. E 4.2 % Chromat. F 5.4 % Chromat.

C4H5N*C2H3N*H(1+) + acetone (67-64-1) → C3H7O(1+)*C2H3N + cyclopropropanecarbonitrile (5500-21-0)

Conditions	Yield
at 24.9℃; Thermodynamic data; ΔG0;

C4H5N*H(1+) + acetone (67-64-1) → 1-hydroxy-1-methyl-ethylium (17104-38-0, 43022-03-3) + cyclopropropanecarbonitrile (5500-21-0)

Conditions	Yield
at 24.9℃; Thermodynamic data; ΔG0;

ammonia (7664-41-7) + sodium amide + 4-bromobutanenitrile (5332-06-9) + iron (III)-nitrate hydrate → cyclopropropanecarbonitrile (5500-21-0)

4-Chlorobutyronitrile (628-20-6) + ammonia (7664-41-7) + sodium amide → cyclopropropanecarbonitrile (5500-21-0)

4-Chlorobutyronitrile (628-20-6) + potassium hydroxide → cyclopropropanecarbonitrile (5500-21-0)

Conditions	Yield
at 85℃;

4-Chlorobutyronitrile (628-20-6) + ammonia (7664-41-7) + potassium hydroxide → cyclopropropanecarbonitrile (5500-21-0)

cyclopropyl isocyanide (58644-53-4) → but-2-enenitrile (4786-20-3) + but-3-enenitrile (109-75-1) + cyclopropropanecarbonitrile (5500-21-0)

Conditions	Yield
at 999.84℃; under 0.0750075 Torr; Gas phase;	A 56 %Spectr. B 16 %Spectr. C 12 %Spectr.

cyclopropanemethylamine (2516-47-4) → cyclopropropanecarbonitrile (5500-21-0)

Conditions	Yield
With copper(l) iodide; oxygen In dichloromethane at 20℃; under 760.051 Torr; for 6h; Sealed tube;	72 %Spectr.

ethanol (64-17-5) + cyclopropropanecarbonitrile (5500-21-0) → cyclopropanecarboximidic Acid Ethyl Ester Hydrochloride (63190-44-3)

Conditions	Yield
With hydrogenchloride In 1,4-dioxane at 20℃;	100%
With hydrogenchloride In 1,4-dioxane at 20℃;	100%
With hydrogenchloride In 1,4-dioxane at 20℃; for 12h; Inert atmosphere;	90%

antimony pentafluoride (7783-70-2) + cyclopropropanecarbonitrile (5500-21-0) → C4H5N*F5Sb

Conditions	Yield
at -196 - -64℃; for 0.166667h; Sealed tube;	100%

cyclopropropanecarbonitrile (5500-21-0) → C4H5N*AsF5

Conditions	Yield
With arsenic pentafluoride at -196 - -64℃; for 0.166667h; Sealed tube;	100%

cyclopropropanecarbonitrile (5500-21-0) + 8-[Chloro-(toluene-4-sulfinyl)-methylene]-1,4-dioxa-spiro[4.5]decane (209391-72-0) → C20H24ClNO3S (1381757-95-4)

Conditions	Yield
With lithium diisopropyl amide	99%

1-(2-(methylthio)-4-(trifluoromethyl)phenyl)ethanone (178462-92-5) + cyclopropropanecarbonitrile (5500-21-0) → C14H14F3NOS

Conditions	Yield
With sodium t-butanolate In 2-methyltetrahydrofuran at 40℃; for 3h; Temperature; Inert atmosphere;	99%

cyclopropropanecarbonitrile (5500-21-0) → (aminomethyl)cyclopropane hydrochloride (7252-53-1)

Conditions	Yield
Stage #1: cyclopropropanecarbonitrile With cobalt pivalate; 1,1,3,3-Tetramethyldisiloxane; tert-butylisonitrile at 80℃; for 24h; Stage #2: With hydrogenchloride In diethyl ether at 20℃; for 0.5h;	98%
With hydrogenchloride; dimethylsulfide borane complex 1.) reflux, 0.25 h, 2.) MeOH, reflux, 4h; Yield given. Multistep reaction;

cyclopropropanecarbonitrile (5500-21-0) + phenylboronic acid (98-80-6) → cyclopropyl phenyl ketone (3481-02-5)

Conditions	Yield
With trifluorormethanesulfonic acid; palladium diacetate; 2-(3,5-dimethyl-1H-pyrazol-1-yl)pyridine In water at 60℃; for 6h;	98%
With [2,2]bipyridinyl; palladium diacetate; trifluoroacetic acid In tetrahydrofuran; water at 80℃; for 36h; Schlenk technique; Inert atmosphere;	83%
With 1,2-bis(diphenylphosphino)ethane nickel(II) chloride; water; zinc(II) chloride In 1,4-dioxane at 80℃; for 8h; Inert atmosphere;	82%

methanol (67-56-1) + cyclopropropanecarbonitrile (5500-21-0) → cyclopropanecarboximidic acid methyl ester monohydrochloride (77570-14-0)

Conditions	Yield
With hydrogenchloride In diethyl ether at 0℃; for 24h;	97%
With hydrogenchloride at -10℃; for 5h;	97%
With hydrogenchloride In diethyl ether at 0 - 20℃; for 17h;	95.5%
With hydrogenchloride In 1,4-dioxane at 0 - 5℃; for 3h;	783 mg

cyclopropropanecarbonitrile (5500-21-0) → cyclopropanecarbothioamide (20295-34-5)

Conditions	Yield
With sodium hydrogensulfide; diethyl amine hydrochloride In 1,4-dioxane; water at 55℃; for 42h;	97%
With tetraphosphorus decasulfide In ethanol at 0 - 60℃;

cyclopropropanecarbonitrile (5500-21-0) + tert-butyl alcohol (75-65-0) → N-(tert-butyl)cyclopropanecarboxamide (15924-91-1)

Conditions	Yield
With silica boron-sulfuric acid nanoparticles at 20℃; for 0.25h; Ritter reaction; Neat (no solvent);	97%
With silica-bonded N-propylsulphamic acid In neat (no solvent) at 80℃; for 1.33333h; Ritter Amidation; Green chemistry;	96%
With bismuth(lll) trifluoromethanesulfonate; water at 100℃; Ritter reaction;	95%

cyclopropropanecarbonitrile (5500-21-0) + rac-3-bromocyclohexene (1521-51-3) → 1-(cyclohex-2-enyl)cyclopropanecarbonitrile (1352832-71-3)

Conditions	Yield
With n-butyllithium; ammonium chloride; diisopropylamine In tetrahydrofuran	97%

pinacolborane + cyclopropropanecarbonitrile (5500-21-0) → C20H39B2N

Conditions	Yield
With sodium triethylborohydride In neat (no solvent) at 80℃; for 24h; Inert atmosphere; Glovebox; Green chemistry;	97%

dimethyl 2,2-di(prop-2-ynyl)malonate (63104-44-9) + cyclopropropanecarbonitrile (5500-21-0) → C15H17NO4 (1516760-82-9)

Conditions	Yield
With η6-(naphtalene)(η5-cyclopentadienyl)-iron(II) hexafluorophosphate; tris(2,4,6-trimethoxyphenyl)phosphine In toluene at 120℃; Inert atmosphere; Schlenk technique; Microwave irradiation;	96%

isopropylhydrazine hydrochloride (70629-60-6, 73941-11-4, 16726-41-3) + cyclopropropanecarbonitrile (5500-21-0) → 3,5-dicyclopropyl-1-isopropyl-1H-1,2,4-triazole

Conditions	Yield
With potassium tert-butylate In 1,4-dioxane at 120℃; for 15h; Inert atmosphere; Sealed tube;	96%

cyclopropropanecarbonitrile (5500-21-0) + prenyl bromide (870-63-3) → 1-(3-methylbut-2-enyl)cyclopropanecarbonitrile (95647-30-6)

Conditions	Yield
With n-butyllithium; ammonium chloride; diisopropylamine In tetrahydrofuran	95%

1-Phenylethanol (98-85-1, 13323-81-4) + cyclopropropanecarbonitrile (5500-21-0) → N-(1-phenylethyl)cyclopropanecarboxamide (78172-92-6)

Conditions	Yield
With silica boron-sulfuric acid nanoparticles at 20℃; for 0.166667h; Ritter reaction; Neat (no solvent);	95%

2-amino-5-bromobenzoic acid,ethyl ester (63243-76-5) + cyclopropropanecarbonitrile (5500-21-0) → 6-bromo-2-cyclopropyl-quinazolin-4-ol

Conditions	Yield
With hydrogenchloride In 1,4-dioxane Reflux;	95%
With hydrogenchloride In 1,4-dioxane; water Reflux;

t-butyl malonate (541-16-2) + cyclopropropanecarbonitrile (5500-21-0) → N-(tert-butyl)cyclopropanecarboxamide (15924-91-1)

Conditions	Yield
In neat (no solvent) at 80℃; for 2h; Ritter Amidation;	95%

6-bromo-1H-indazole (79762-54-2) + cyclopropropanecarbonitrile (5500-21-0) → 1-(1H-indazol-6-yl)cyclopropane-1-carbonitrile

Conditions	Yield
With N-Xantphos Pd G4; lithium hexamethyldisilazane In tetrahydrofuran at 20℃; for 0.25h; Inert atmosphere; Sealed tube;	95%

cyclopropropanecarbonitrile (5500-21-0) → cyclopropylcarboxamidine hydrochloride (57297-29-7)

Conditions	Yield
Stage #1: cyclopropropanecarbonitrile With hydrogenchloride; methanol In toluene at 15 - 23℃; for 18h; Stage #2: With ammonia In methanol; toluene at 5 - 25℃; for 1.16667h;	94%
Stage #1: cyclopropropanecarbonitrile With hydrogenchloride In ethanol at 20℃; for 24h; Stage #2: With ammonia In ethanol at 23℃; Cooling with ice;	79.5%
Stage #1: cyclopropropanecarbonitrile With hydrogenchloride; methanol In diethyl ether at 0℃; for 2h; Stage #2: With ammonia In methanol for 1h; Cooling with ice;	67%

cyclopropropanecarbonitrile (5500-21-0) → cyclopropanecarboxamide oxime (51285-13-3)

Conditions	Yield
With hydroxylamine In ethanol; water at 80℃;	94%
With hydroxylamine hydrochloride; sodium hydrogencarbonate In isopropyl alcohol at 80 - 85℃;	70%
With hydroxylamine hydrochloride; sodium hydrogencarbonate In ethanol for 6h; Reflux;	52%

N-hydroxybenzenecarboximidamide (613-92-3) + cyclopropropanecarbonitrile (5500-21-0) → 5-cyclopropyl-3-phenyl-1,2,4-oxadiazole (884637-65-4)

Conditions	Yield
With toluene-4-sulfonic acid; zinc(II) chloride In N,N-dimethyl-formamide at 80℃; Inert atmosphere;	94%

phosphonic acid diethyl ester (762-04-9) + cyclopropropanecarbonitrile (5500-21-0) → C12H27NO6P2 (1351078-23-3)

Conditions	Yield
With bis(cyclopentadienyl)titanium dichloride; methyloxirane; zinc In tetrahydrofuran for 20h; Inert atmosphere; Reflux;	94%

1,1-Diphenylmethanol (91-01-0) + cyclopropropanecarbonitrile (5500-21-0) → N-(diphenylmethyl)cyclopropylcarboxamide (545437-24-9)

Conditions	Yield
With silica-bonded N-propylsulphamic acid In neat (no solvent) at 80℃; for 0.416667h; Ritter Amidation; Green chemistry;	94%

styrene (292638-84-7) + 2-((trifluoromethyl)thio)benzo[d]isothiazol-3(2H)-one 1,1-dioxide + cyclopropropanecarbonitrile (5500-21-0) → N-(1-phenyl-2-((trifluoromethyl)thio)ethyl)cyclopropanecarboxamide

Conditions	Yield
With trifluorormethanesulfonic acid; bis(4-methoxyphenyl)selenide In hexane; water at 20℃; for 24h; Sealed tube;	94%

Diphenylmethane (101-81-5) + cyclopropropanecarbonitrile (5500-21-0) → N-(diphenylmethyl)cyclopropylcarboxamide (545437-24-9)

Conditions	Yield
With manganese(II) acetate dihydrate; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone In 1,2-dichloro-ethane at 90℃; for 12h; Inert atmosphere;	94%
With manganese(III) triacetate dihydrate; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone In 1,2-dichloro-ethane at 90℃; for 12h; Schlenk technique; Inert atmosphere;	90%

Upstream product

• 628-20-6 4-Chlorobutyronitrile 
• 141-52-6 sodium ethanolate 
• 107-13-1 acrylonitrile 
• 74-95-3 1,1-dibromomethane 
• 100-52-7 benzaldehyde 
• 6914-79-0 1-cyano-cyclopropanecarboxylic acid 
• 6727-73-7 4-iodobutyronitrile 
• 2516-47-4 cyclopropanemethylamine 
• 58644-53-4 cyclopropyl isocyanide 
• 104-55-2 3-phenyl-propenal 
• 104-88-1 4-chlorobenzaldehyde 
• 104-87-0 4-methyl-benzaldehyde 
• 7664-41-7 ammonia 
• 5332-06-9 4-bromobutanenitrile 

Downstream Products

• 756488-62-7 N-(cyclopropyl)methylbenzamide 
• 187827-14-1 (Z)-3-amino-3-cyclopropylacrylic acid ethyl ester 
• 203441-62-7 3-(cyclopropanecarboximidoyl-amino)-4-methoxy-benzoic acid methyl ester 
• 101-05-3 anilazine 
• 150322-73-9 1-cyclopropyl-2-(2-fluorophenyl)ethanone 
• 95-52-3 2-Fluorotoluene 
• 446-51-5 2-fluorobenzyl alcohol 
• 4786-20-3 but-2-enenitrile 
• 107-13-1 acrylonitrile 
• 109-75-1 but-3-enenitrile 
• 198144-76-2 cis-Pt(Ph₂SO)(cyclo-propylcarbonitrile)Cl₂ 
• 198227-87-1 [Pt(Ph2SO)Cl(μ-NHC(cyclo-C3H5)O)]2 
• 77570-31-1 3-amino-3-cyclopropyl-acrylic acid ethyl ester 
• 134128-48-6 1-(4-fluorobenzoyl)cyclopropanecarbonitrile 

Relevant articles and documents

Direct Evidence for the Hydroxide Extraction Mechanism in the Phase Transfer Catalyzed Cyclopropanation of 4-Halobutyronitrile in a Solid-Liquid System

The Hoffman degradation reaction is proposed as an unequivocal proof for the validity of the extraction mechanism in Phase Transfer Catalysis (PTC) in the presence of solid NaOH. 4-Chlorobutyronitrile is found to yield cyclopropyl cyanide via an extraction route while 4-bromobutyronitrile reacts to form the same product by the prevalent interfacial mechanism.

Novel method and technology for synthesizing cyclopropyl ammonia

The invention discloses a synthesis process route of a cyclopropane synthetic route. In the process route, cyanocyclopropane 1 - formic acid (-1 -) and (1) are subjected to hydrolysis under the action of a strong base to generate 1-cyanocyclopropane 1 - formic acid (-1 -), (2) decarboxylation to generate cyclopropanecarboxamide (2 3), and (4 4 3) subjected to Hoffman rearrangement to obtain the target product cyclopropysite. The process route is longer than the production process in the present stage, the reaction route is long, the use of high-temperature and high-pressure is avoided, the danger is reduced, and the safety is improved. The requirement of the reaction equipment is reduced, the used raw materials are easy to obtain, operation is easy, safety and environmental protection are achieved, and industrial production can be realized.

Synthetic method of cyclopropanecarbonitrile

The invention discloses a synthetic method of cyclopropanecarbonitrile. Cyclopropanecarbonitrile is prepared from a 4-halogenated butyronityile compound under the action of dihydric alcohol and sodium. The method has the advantages of simplicity in operation, fast reaction and high yield, solves the problem of simple and fast synthesis of the cyclopropanecarbonitrile compound, and can be used to prepare cyclopropanecarbonitrile.