Aklavin

Base Information

Chemical Name:Aklavin
CAS No.:60504-57-6
Deprecated CAS:11002-83-8
Molecular Formula:C₃₀H₃₅NO₁₀
Molecular Weight:569.609
Hs Code.:
UNII:T87WN25BNW
DSSTox Substance ID:DTXSID30209246
Nikkaji Number:J17.925F
Wikidata:Q27105019
ChEMBL ID:CHEMBL3040622
Mol file:60504-57-6.mol

Synonyms:aclacinomycin;aclacinomycin B;aclacinomycin Hydrochloride;aclacinomycin M;aclacinomycin N;aclacinomycin S;aclacinomycin T;aclacinomycin X;aclacinomycin Y;aclacinomycins;MA 144 N1;MA 144 S1;siwenmycin

Suppliers and Price of Aklavin

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Aklavine
1mg
$ 170.00

American Custom Chemicals Corporation
AKLAVINE 95.00%
5MG
$ 503.21

Total 6 raw suppliers

Chemical Property of Aklavin

Chemical Property:

Vapor Pressure:1.2E-22mmHg at 25°C
Refractive Index:1.6310 (estimate)
Boiling Point:734.5°C at 760 mmHg
Flash Point:398°C
PSA：163.06000
Density:1.2894 (rough estimate)
LogP:2.15830
XLogP3:3.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:11
Rotatable Bond Count:6
Exact Mass:569.22609631
Heavy Atom Count:41
Complexity:1020

Purity/Quality:

99% ^*data from raw suppliers

Aklavine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1(CC(C2=C(C3=C(C=C2C1C(=O)OC)C(=O)C4=C(C3=O)C(=CC=C4)O)O)OC5CC(C(C(O5)C)O)N(C)C)O
Isomeric SMILES:CC[C@]1(C[C@@H](C2=C(C3=C(C=C2[C@H]1C(=O)OC)C(=O)C4=C(C3=O)C(=CC=C4)O)O)O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)N(C)C)O
Recent ClinicalTrials:Selinexor and HAAG With/Without HMA in Relapsed/Refractory Acute Leukemia (AML) Patients

Technology Process of Aklavin

There total 16 articles about Aklavin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78773-17-8,78773-18-9,78773-19-0,78773-20-3
9-epi-aklavinone 7-methyl ether

: 60504-57-6,11002-83-8
aklavin

Guidance literature:: Multi-step reaction with 5 steps

1: 11 percent / potassium carbonate / methanol / 1.75 h / 65 °C

2: trifluoroacetic acid / Ambient temperature

3: 30 percent / p-toluenesulfonic acid monohydrate / benzene / 50 °C

4: sodium methoxide / methanol / 2 h / -20 °C

5: NaBH₃CN, AcOH / H₂O / 1 h / Ambient temperature

With sodium methylate; sodium cyanoborohydride; potassium carbonate; toluene-4-sulfonic acid; acetic acid; trifluoroacetic acid; In methanol; water; benzene;
DOI:10.1021/ja00404a047

Reference yield:

: 78773-17-8,78773-18-9,78773-19-0,78773-20-3
7-epi-aklavinone 7-methyl ether

: 60504-57-6,11002-83-8
aklavin

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / Ambient temperature

2: 30 percent / p-toluenesulfonic acid monohydrate / benzene / 50 °C

3: sodium methoxide / methanol / 2 h / -20 °C

4: NaBH₃CN, AcOH / H₂O / 1 h / Ambient temperature

With sodium methylate; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; trifluoroacetic acid; In methanol; water; benzene;
DOI:10.1021/ja00404a047

Reference yield:

: 78773-17-8,78773-18-9,78773-19-0,78773-20-3
aklavinone 7-methyl ether

: 60504-57-6,11002-83-8
aklavin

Guidance literature:: Multi-step reaction with 4 steps

1: trifluoroacetic acid / Ambient temperature

2: 30 percent / p-toluenesulfonic acid monohydrate / benzene / 50 °C

3: sodium methoxide / methanol / 2 h / -20 °C

4: NaBH₃CN, AcOH / H₂O / 1 h / Ambient temperature

With sodium methylate; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; trifluoroacetic acid; In methanol; water; benzene;
DOI:10.1021/ja00404a047