3-Methyl-1,2,4-triazolo[4,3-a]pyridine

Base Information

• Chemical Name: 3-Methyl-1,2,4-triazolo[4,3-a]pyridine
• CAS No.: 1004-65-5
• Molecular Formula: C₇H₇N₃
• Molecular Weight: 133.153
• Hs Code.: 2933990090
• Mol file: 1004-65-5.mol

Synonyms:s-Triazolo[4,3-a]pyridine,3-methyl- (6CI,7CI,8CI);3-Methyl-s-triazolo[4,3-a]pyridine;NSC 68458;

Chemical Property of 3-Methyl-1,2,4-triazolo[4,3-a]pyridine

Chemical Property:

• Melting Point: 134℃
• Refractive Index: 1.658
• PKA: 3.97±0.50(Predicted)
• PSA: 30.19000
• Density: 1.24 g/cm³
• LogP: 1.03770
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

3-Methyl-[1,2,4]triazolo[4,3-a]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Methyl-1,2,4-triazolo[4,3-a]pyridine

There total 5 articles about 3-Methyl-1,2,4-triazolo[4,3-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

pyrid-2-ylhydrazine (4930-98-7) + N,N-dimethyl acetamide (127-19-5,116057-81-9) → 3-methyl-s-triazolo<4,3-a>pyridin (1004-65-5)

Guidance literature:

With Imidazole hydrochloride; at 153 ℃;

DOI:10.1016/j.tetlet.2020.151844

Reference yield: 36.0%

pyrid-2-ylhydrazine (4930-98-7) + N-acetylglycine (543-24-8) → N-([1,2,4]triazolo[4,3-a]pyridin-3-ylmethyl)acetamide + 3-methyl-s-triazolo<4,3-a>pyridin (1004-65-5)

Guidance literature:

at 140 - 150 ℃; for 5h;

DOI:10.1515/HC.2005.11.3-4.321

Reference yield:

acetic acid N'-pyridin-2-yl-hydrazide (7707-99-5) → 3-methyl-s-triazolo<4,3-a>pyridin (1004-65-5)

Guidance literature:

With acetic acid; at 180 ℃; for 0.5h; Microwave irradiation;

DOI:10.1021/ol902868q

upstream raw materials:

pyrid-2-ylhydrazine

acetic anhydride

N-acetylglycine

acetic acid N'-pyridin-2-yl-hydrazide

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