7-Aminoquinoline

Base Information

• Chemical Name: 7-Aminoquinoline
• CAS No.: 580-19-8
• Molecular Formula: C9H8 N2
• Molecular Weight: 144.176
• Hs Code.: 2933499090
• European Community (EC) Number: 811-260-7
• NSC Number: 58389
• UNII: CDC9L46LG6
• DSSTox Substance ID: DTXSID60206728
• Nikkaji Number: J79.671I
• Wikidata: Q56119216
• ChEMBL ID: CHEMBL2138860
• Mol file: 580-19-8.mol

Synonyms:7-Aminoquinoline;quinolin-7-amine;580-19-8;7-Quinolinamine;7-Quinolylamine;QUINOLINE, 7-AMINO-;CCRIS 1682;MFCD01646243;NSC 58389;BRN 0113310;CDC9L46LG6;NSC-58389;5-22-10-00313 (Beilstein Handbook Reference);7-Amino-quinoline;7-aminequinoline;7-amine-quinoline;7-Quinolinamine (9CI);UNII-CDC9L46LG6;7-Aminoquinoline, AldrichCPR;SCHEMBL118900;CHEMBL2138860;DTXSID60206728;NSC58389;BBL103368;STL557178;AKOS000276867;CS-W018597;SB67547;NCGC00184186-01;AM807087;AS-18425;SY021164;LS-141300;FT-0645213;A26288;EN300-124532;J-519079;Quinolin-7-ylamine;Quinolin-7-amine

Chemical Property of 7-Aminoquinoline

Chemical Property:

• Vapor Pressure: 0.000247mmHg at 25°C
• Melting Point: 93.5-94 °C
• Boiling Point: 324.3°Cat760mmHg
• PKA: 6.60±0.14(Predicted)
• Flash Point: 176.1°C
• PSA: 38.91000
• Density: 1.21g/cm³
• LogP: 2.39820
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 144.068748264
• Heavy Atom Count: 11
• Complexity: 136

Purity/Quality:

99% ^*data from raw suppliers

7-Aminoquinoline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=C(C=C(C=C2)N)N=C1
• Uses: 7-Aminoquinoline Is an aminoquinolines derivative with antiviral activity.

Technology Process of 7-Aminoquinoline

There total 9 articles about 7-Aminoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

7-amino-1,2,3,4-tetrahydroquinoline (153856-89-4) + nitrobenzene (98-95-3,26969-40-4) → quinolin-7-ylamine (580-19-8) + aniline (62-53-3)

Guidance literature:

With nickel-nitrogen-doped carbon framework; In water; at 145 ℃; for 18h; Inert atmosphere; Sealed tube; Green chemistry;

DOI:10.1039/c9gc04358f

Reference yield: 60.0%

7-amino-1,2,3,4-tetrahydroquinoline (153856-89-4) + 3-ethylnitrobenzene (7369-50-8) → quinolin-7-ylamine (580-19-8) + m-ethylaniline (587-02-0)

Guidance literature:

With nickel-nitrogen-doped carbon framework; In water; at 145 ℃; for 18h; Inert atmosphere; Sealed tube; Green chemistry;

DOI:10.1039/c9gc04358f

Reference yield: 57.0%

7-azidoquinoline → quinolin-7-ylamine (580-19-8) + 8-Amino-7-cyclohexylaminochinolin (65417-78-9)

Guidance literature:

With cyclohexylamine; Ambient temperature; Irradiation;

upstream raw materials:

cyclohexylamine

5-nitroquinoline

7-nitroquinoline

7-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline

Downstream raw materials:

N-(quinolin-7-yl)acetamide

N-[7]quinolyl-benzamide

4-methyl-N-(quinolin-7-yl)benzenesulfonamide

quinolin-7-ol

Refernces

• 1、 Ham, Won Seok,Hillenbrand, Julius,Jacq, Jér?me,Genicot, Christophe,Ritter, Tobias. "Divergent Late-Stage (Hetero)aryl C?H Amination by the Pyridinium Radical Cation". supporting information. p. 532 - 536. Retrieved 2019/01/04.
• 2、 -. "Tricyclic steroid receptor modulator compounds and methods". . . Retrieved 2008/06/13.