3-Hydroxy-2-methylpyridine

Base Information

• Chemical Name: 3-Hydroxy-2-methylpyridine
• CAS No.: 1121-25-1
• Molecular Formula: C6H7NO
• Molecular Weight: 109.128
• Hs Code.: 29333990
• European Community (EC) Number: 214-327-3
• NSC Number: 27506
• UNII: 365FJ23A8Z
• DSSTox Substance ID: DTXSID40149907
• Nikkaji Number: J141.788F
• Wikidata: Q27256528
• Metabolomics Workbench ID: 163619
• ChEMBL ID: CHEMBL134348
• Mol file: 1121-25-1.mol

Synonyms:3-Hydroxy-2-methylpyridine;2-Methylpyridin-3-ol;1121-25-1;3-Hydroxy-2-picoline;2-Methyl-3-hydroxypyridine;2-Methyl-3-pyridinol;3-Pyridinol, 2-methyl-;MFCD00082538;3-Pyridinol, methyl-;55780-69-3;2-Methyl-pyridin-3-ol;UNII-365FJ23A8Z;3-Hydroxy-2-methylpyridine-d3;365FJ23A8Z;EINECS 214-327-3;NSC-27506;2-Methyl-3-hydroxylpyridine;NSC27506;2methylpyridin-3-ol;2-methyl-3-pyridol;2-methylpyridine-3-ol;2-methyl-pyridine-3-ol;3-hydroxyl-2-methylpyridine;2-methyl 3-hydroxy pyridine;2-methyl-3-hydroxy-pyridine;3-hydroxy-2-methyl pyridine;SCHEMBL118678;CHEMBL134348;DTXSID40149907;3-Hydroxy-2-methylpyridine, 99%;BCP26772;STR06099;CL0055;NSC 27506;AKOS005145808;AC-5084;CS-W002339;HY-W002339;PB18442;PS-9276;SB10555;BP-12767;SY007645;A2234;AM20061689;FT-0615806;FT-0669845;H1365;EN300-55470;AQ-344/40575762;W-200835;Q27256528;F0001-0267

Chemical Property of 3-Hydroxy-2-methylpyridine

Chemical Property:

• Appearance/Colour: beige-brown powder
• Vapor Pressure: 0.00147mmHg at 25°C
• Melting Point: 168-169 °C(lit.)
• Refractive Index: 1.55
• Boiling Point: 287.1 °C at 760 mmHg
• PKA: 10.38±0.10(Predicted)
• Flash Point: 127.4 °C
• PSA: 33.12000
• Density: 1.12 g/cm³
• LogP: 1.09560
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: DMSO, Methanol
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 109.052763847
• Heavy Atom Count: 8
• Complexity: 74.9

Purity/Quality:

99% ^*data from raw suppliers

3-Hydroxy-2-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,Xi
• Statements: 22-37/38-41-36/37/38
• Safety Statements: 26-37/39-36/37/39-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=C(C=CC=N1)O
• Uses: 3-Hydroxy-2-methylpyridine is used in the preparation of substituted pyridine and pyrimidine derivatives and their use in treating viral infections. 3-Hydroxy-2-methylpyridine was used in the synthesis of pyrimidine.

Technology Process of 3-Hydroxy-2-methylpyridine

There total 32 articles about 3-Hydroxy-2-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

α-picoline (109-06-8) → 2-methyl-3-pyridinol (1121-25-1,55780-69-3)

Guidance literature:

With dihydrogen peroxide; copper(II) nitrate; In phosphate buffer; acetonitrile; at 50 ℃; for 4h;

DOI:10.1515/HC.2001.7.5.501

Reference yield: 65.0%

2-[(dimethylamino)methyl]pyridin-3-ol (2168-13-0) → 2-methyl-3-pyridinol (1121-25-1,55780-69-3)

Guidance literature:

With tri-n-butyl-tin hydride; at 200 ℃; for 0.5h;

Reference yield: 60.0%

(2S)-1-benzyl-2-methyl-1,6-dihydropyridin-3(2H)-one (1000414-75-4) → 2-methyl-3-pyridinol (1121-25-1,55780-69-3) + (2S)-1-benzyl-2-methylpiperidin-3-one (1072088-64-2)

Guidance literature:

With palladium hydroxide on carbon; hydrogen; In ethyl acetate; at 20 ℃; for 20h; chemoselective reaction;

DOI:10.1002/ejoc.200800380

upstream raw materials:

2-methylpyridine N-oxide

acetic anhydride

1-(2-furyl)-1-ethanone

2-bromomethyl-3-hydroxypyridine hydrobromide

Downstream raw materials:

2-trans-styryl-pyridin-3-ol

3-hydroxy-2-methylpyridine 1-oxide

2-bromo-5-hydroxyl-6-methylpyridine

2,4-dibromo-3-hydroxyl-6-methylpyridine

Refernces

• 1、 Williams et al.. "-". . p. 1139,1142. Retrieved 1955.
• 2、 Jida, Mouhamad,Ollivier, Jean. "Convergent and selective synthesis of pyrrolidinones, piperidinones, dihydropyridinones and pyridinols from a common intermediate - Potential precursors of bioactive products". experimental part. p. 4041 - 4049. Retrieved 2009/04/14.
• 3、 An, Jia-Ning,Meng, Xiang-Bao,Yao, Yun,Li, Zhong-Jun. "A facile synthesis of 1,6-dideoxynojirimycin from l-sorbose". . p. 2200 - 2203. Retrieved 2007/10/03.