2168-13-0

Basic information

• Product Name: 2-(Dimethylaminomethyl)-3-hydroxypyridine
• Synonyms: 2-(DIMETHYLAMINOMETHYL)-3-HYDROXYPYRIDINE;2-DIMETHYLAMINOMETHYL-3-PYRIDINOL;2(-DIMETHYLAMINOMETHYL)-3-PYRIDOL;3-Pyridinol, 2-[(dimethylamino)methyl]-;2-[(dimethylamino)methyl]pyridin-3-ol;3-Hydroxy-2-(dimethylaminomethyl)-pyridine;2-(DIMETHYLAMINOMETHYL)-3-HYDROXYPYRIDINE 97%;2-(Dimethylaminomethyl)pyridine-3-ol
• CAS NO: 2168-13-0
• Molecular Formula: C₈H₁₂N₂O
• Molecular Weight: 152.19
• EINECS: 218-510-9
• Mol File: 2168-13-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 56-59 °C(lit.)
• Boiling Point: 98 °C4 mm Hg(lit.)
• Flash Point: 128.1 °C
• Appearance: /
• Density: 1.0996 (rough estimate)
• Vapor Pressure: 0.0241mmHg at 25°C
• Refractive Index: 1.4940 (estimate)
• PKA: 8.79±0.10(Predicted)
• CAS DataBase Reference: 2-(Dimethylaminomethyl)-3-hydroxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Dimethylaminomethyl)-3-hydroxypyridine(2168-13-0)
• EPA Substance Registry System: 2-(Dimethylaminomethyl)-3-hydroxypyridine(2168-13-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• Hazardous Substances Data: 2168-13-0(Hazardous Substances Data)

Usage

Chemical Properties

white to beige crystalline powder

InChI:InChI=1/C8H12N2O/c1-10(2)6-7-8(11)4-3-5-9-7/h3-5,11H,6H2,1-2H3/p+1

Upstream product

• 109-00-2 3-HYDROXYPYRIDINE 
• 50-00-0 formaldehyd 
• 124-40-3 dimethyl amine 

Downstream Products

• 59801-39-7 2-Isobutyloxy-5-azachroman 
• 59801-38-6 2-Ethoxy-5-azachroman 
• 109-00-2 3-HYDROXYPYRIDINE 
• 65974-47-2 2-[(phenylimino)methyl]-1-azabenzene-3-ol 
• 74803-54-6 2-[(phenylamino)methyl]-1-azabenzene-3-ol 
• 1121-25-1 2-methyl-3-pyridinol 
• 66967-89-3 (3-acetoxy-[2]pyridylmethyl)-trimethyl-ammonium; bromide 

Relevant articles and documents

Demonstration of in Vitro Resurrection of Aged Acetylcholinesterase after Exposure to Organophosphorus Chemical Nerve Agents

After the inhibition of acetylcholinesterase (AChE) by organophosphorus (OP) nerve agents, a dealkylation reaction of the phosphylated serine, referred to as aging, can occur. When aged, known reactivators of OP-inhibited AChE are no longer effective. Realkylation of aged AChE may provide a route to reversing aging. We designed and synthesized a library of quinone methide precursors (QMPs) as proposed realkylators of aged AChE. Our lead compound (C8) from an in vitro screen successfully resurrected 32.7 and 20.4% of the activity of methylphosphonate-aged and isopropyl phosphate-aged electric-eel AChE, respectively, after 4 days. C8 displays properties of both resurrection (recovery from the aged to the native state) and reactivation (recovery from the inhibited to the native state). Resurrection of methylphosphonate-aged AChE by C8 was significantly pH-dependent, recovering 21% of activity at 4 mM and pH 9 after only 1 day. C8 is also effective against isopropyl phosphate-aged human AChE.

TRICYCLIC COMPOUND AND MEDICAL USE THEREOF

The present invention provides a compound represented by the formula wherein R1 is a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or a heterocyclic group optionally having substituent(s), R2 is a hydrogen atom or a hydrocarbon group optionally having substituent(s), R3 is a hydrogen atom, a halogen atom, a hydrocarbon group optionally having substituent(s), amino optionally having substituent(s), hydroxy optionally having a substituent or mercapto optionally having a substituent, Xa to Xe are each a carbon atom or a nitrogen atom, m is 0 to 2, and ring A to ring C are each a ring optionally having substituent(s), or a salt thereof, which is useful as an agent for the prophylaxis or treatment of a disease relating to an action of melatonin, and the like.