2-Cyclopropene-1-carboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-phenyl-, methyl ester, (R)-

Base Information

• Chemical Name: 2-Cyclopropene-1-carboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-phenyl-, methyl ester, (R)-
• CAS No.: 113489-60-4
• Molecular Formula: C₁₆H₁₉NO₄
• Molecular Weight: 289.331
• Mol file: 113489-60-4.mol

Synonyms:

Chemical Property of 2-Cyclopropene-1-carboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-phenyl-, methyl ester, (R)-

Chemical Property:

Purity/Quality:

99.90% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Cyclopropene-1-carboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-phenyl-, methyl ester, (R)-

There total 4 articles about 2-Cyclopropene-1-carboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-2-phenyl-, methyl ester, (R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (3R,6S)-6-Isopropyl-5,8-dimethoxy-1-phenyl-4,7-diaza-spiro[2.5]octa-1,4,7-triene (113489-54-6) → L-Valine methyl ester (4070-48-8) + (R)-N-Boc-1-amino-2-phenyl-cyclopropen-1-carbonsaeuremethylester (113489-60-4) + (S)-N-Boc-1-amino-2-phenyl-cyclopropencarbonsaeuremethylester (113489-60-4)

Guidance literature:

With hydrogenchloride; triethylamine; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1) MeCN, 2 days, 2) CH₂Cl₂, 4 h, 0 deg C;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (3R,6S)-6-Isopropyl-5,8-dimethoxy-1-phenyl-4,7-diaza-spiro[2.5]octa-1,4,7-triene (113489-54-6) → L-Valine methyl ester (4070-48-8) + (R)-N-Boc-1-amino-2-phenyl-cyclopropen-1-carbonsaeuremethylester (113489-60-4) + (S)-N-Boc-1-amino-2-phenyl-cyclopropencarbonsaeuremethylester (113489-60-4)

Guidance literature:

With hydrogenchloride; triethylamine; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1) MeCN, 2 days, 2) CH₂Cl₂, 4 h, 0 deg C;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (3S,6R)-6-Isopropyl-5,8-dimethoxy-1-phenyl-4,7-diaza-spiro[2.5]octa-1,4,7-triene (113489-54-6) → D-Valine methyl ester (4070-48-8,18869-42-6,21685-47-2) + (R)-N-Boc-1-amino-2-phenyl-cyclopropen-1-carbonsaeuremethylester (113489-60-4) + (S)-N-Boc-1-amino-2-phenyl-cyclopropencarbonsaeuremethylester (113489-60-4)

Guidance literature:

With hydrogenchloride; triethylamine; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts; 1) MeCN, 2 days, 2) CH₂Cl₂, 4 h, 0 deg C;

upstream raw materials:

di-tert-butyl dicarbonate

(3R,6S)-6-Isopropyl-5,8-dimethoxy-1-phenyl-4,7-diaza-spiro[2.5]octa-1,4,7-triene

(3S,6R)-6-Isopropyl-5,8-dimethoxy-1-phenyl-4,7-diaza-spiro[2.5]octa-1,4,7-triene

Refernces