(3S,5S)-3-(4-chlorophenyl)-5-(2,6-dichlorophenyl)-3-(1H-imidazol-1-ylmethyl)-2-methyl-1,2-oxazolidine

Base Information

• Chemical Name: (3S,5S)-3-(4-chlorophenyl)-5-(2,6-dichlorophenyl)-3-(1H-imidazol-1-ylmethyl)-2-methyl-1,2-oxazolidine
• CAS No.: 113614-54-3
• Molecular Formula: C₂₀H₁₈Cl₃N₃O
• Molecular Weight: 422.741
• Mol file: 113614-54-3.mol

Synonyms:

Chemical Property of (3S,5S)-3-(4-chlorophenyl)-5-(2,6-dichlorophenyl)-3-(1H-imidazol-1-ylmethyl)-2-methyl-1,2-oxazolidine

Chemical Property:

• Vapor Pressure: 8.68E-12mmHg at 25°C

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3S,5S)-3-(4-chlorophenyl)-5-(2,6-dichlorophenyl)-3-(1H-imidazol-1-ylmethyl)-2-methyl-1,2-oxazolidine

There total 2 articles about (3S,5S)-3-(4-chlorophenyl)-5-(2,6-dichlorophenyl)-3-(1H-imidazol-1-ylmethyl)-2-methyl-1,2-oxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.4%

2,6-dichlorostyrene (28469-92-3) + 1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-N-methylethanimine N-oxide (119393-45-2,113944-25-5) → trans-3-(4-chlorophenyl)-5-(2,6-dichlorophenyl)-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidine (113614-55-4) + cis-3-(4-chlorophenyl)-5-(2,6-dichlorophenyl)-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidine (113614-54-3)

Guidance literature:

In toluene; for 48h; Heating;

DOI:10.1021/jm00118a027

Reference yield:

1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-one (24155-32-6) → cis-3-(4-chlorophenyl)-5-(2,6-dichlorophenyl)-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidine (113614-54-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOAc / ethanol / 48 h / Ambient temperature

2: 3 percent / toluene / 48 h / Heating

With sodium acetate; In ethanol; toluene;

DOI:10.1021/jm00118a027

upstream raw materials:

2,6-dichlorostyrene

1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-N-methylethanimine N-oxide

1-(4-chlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-one

Refernces