1-NAPHTHYL-(2-PYRIDYL)METHANOL

Base Information

• Chemical Name: 1-NAPHTHYL-(2-PYRIDYL)METHANOL
• CAS No.: 113631-11-1
• Molecular Formula: C16H13NO
• Molecular Weight: 235.28100
• Mol file: 113631-11-1.mol

Synonyms:Naphthalen-1-yl-pyridin-2-yl-methanol;(1-naphthyl)(pyridin-2-yl)methanol;naphthalen-2-yl(pyridine-2-yl)methanol;

Chemical Property of 1-NAPHTHYL-(2-PYRIDYL)METHANOL

Chemical Property:

• Boiling Point: 428.1±30.0 °C(Predicted)
• PKA: 12.53±0.20(Predicted)
• PSA: 33.12000
• Density: 1.210±0.06 g/cm3(Predicted)
• LogP: 3.31650

Purity/Quality:

97% ^*data from raw suppliers

1-NAPHTHYL-(2-PYRIDYL)METHANOL ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-NAPHTHYL-(2-PYRIDYL)METHANOL

There total 8 articles about 1-NAPHTHYL-(2-PYRIDYL)METHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

pyridine-2-carbaldehyde (1121-60-4) + 1-Bromonaphthalene (90-11-9) → naphthalen-2-yl(pyridine-2-yl)methanol (113631-11-1)

Guidance literature:

1-Bromonaphthalene; With magnesium; ethylene dibromide; In diethyl ether; for 1h; Heating;

pyridine-2-carbaldehyde; In diethyl ether; at 20 ℃;

Reference yield: 85.0%

2-bromo-pyridine (109-04-6) + 1-naphthaldehyde (66-77-3) → naphthalen-2-yl(pyridine-2-yl)methanol (113631-11-1)

Guidance literature:

2-bromo-pyridine; With n-butyllithium; butyl magnesium bromide; 1,1'-bi-2-naphthol; In tetrahydrofuran; hexane; at -5 - 20 ℃; for 1h; Inert atmosphere;

1-naphthaldehyde; In tetrahydrofuran; hexane; at -60 - 20 ℃; for 1h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; hexane; water; pH=3 - 4; Inert atmosphere;

DOI:10.1002/ejoc.201101490

Reference yield: 71.0%

1-(1-naphthyl)-1-(2-pyridyl)methane (129414-42-2) → naphthalen-2-yl(pyridine-2-yl)methanol (113631-11-1)

Guidance literature:

With potassium tert-butylate; dimethyl sulfoxide; at 30 ℃; for 0.0666667h; chemoselective reaction;

DOI:10.1021/acs.orglett.0c03108

upstream raw materials:

pyridine-2-carbaldehyde

1-Bromonaphthalene

(naphthalen-1-yl)(pyridin-2-yl)methanone

2-bromo-pyridine

Downstream raw materials:

2-(naphthalen-1-yl(phenyl)methyl)pyridine

naphthalen-1-yl(phenyl)(pyridin-2-yl)methanol