5-AMINO-3-METHYL-ISOTHIAZOLE-4-CARBOXYLIC ACID

Base Information

• Chemical Name: 5-AMINO-3-METHYL-ISOTHIAZOLE-4-CARBOXYLIC ACID
• CAS No.: 22131-51-7
• Molecular Formula: C5H6 N2 O2 S
• Molecular Weight: 158.181
• Hs Code.: 2934999090
• Mol file: 22131-51-7.mol

Synonyms:3-Methyl-5-aminoisothiazole-4-carboxylicacid; 5-Amino-3-methylisothiazole-4-carboxylic acid

Chemical Property of 5-AMINO-3-METHYL-ISOTHIAZOLE-4-CARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 0.0664mmHg at 25°C
• Boiling Point: 220.2°Cat760mmHg
• Flash Point: 86.9°C
• PSA: 104.45000
• Density: 1.532g/cm³
• LogP: 1.31310
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

5-Amino-3-methyl-1,2-thiazole-4-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-AMINO-3-METHYL-ISOTHIAZOLE-4-CARBOXYLIC ACID

There total 1 articles about 5-AMINO-3-METHYL-ISOTHIAZOLE-4-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 5-amino-3-methyl-isothiazole 4-carboxylate (34859-65-9) → 5-amino-3-methyl-1,2-thiazole-4-carboxylic acid (22131-51-7)

Guidance literature:

With sodium hydroxide;

Reference yield: 74.0%

5-amino-3-methyl-1,2-thiazole-4-carboxylic acid (22131-51-7) → 3-methyl-5-aminothiazole (24340-76-9)

Guidance literature:

With sulfuric acid; at 100 - 110 ℃;

DOI:10.1016/j.molstruc.2019.06.028

Reference yield: 44.0%

6-(cyclohexyloxy)pyridin-3-amine (224187-22-8) + 5-amino-3-methyl-1,2-thiazole-4-carboxylic acid (22131-51-7) → 5-amino-N-[6-(cyclohexyloxy)pyridin-3-yl]-3-methyl-1,2-thiazole-4-carboxamide (1621367-94-9)

Guidance literature:

5-amino-3-methyl-1,2-thiazole-4-carboxylic acid; With thionyl chloride; at 80 ℃; for 5h;

6-(cyclohexyloxy)pyridin-3-amine; With triethylamine; In tetrahydrofuran; at 20 ℃; for 2.5h;

upstream raw materials:

ethyl 5-amino-3-methyl-isothiazole 4-carboxylate

Downstream raw materials:

5-(2-chloro-benzoylamino)-3-methyl-isothiazole-4-carboxylic acid

5-amino-3-methyl-4-isothiazolecarboxylic acid chloride

5-(4-chloro-benzoylamino)-3-methyl-isothiazole-4-carboxylic acid

5-(4-chloro-benzoylamino)-3-methyl-isothiazole-4-carboxylic acid ethyl ester

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