Methanone, (3,4-dichloro-5-hydroxyphenyl)phenyl-

Base Information

Chemical Name:Methanone, (3,4-dichloro-5-hydroxyphenyl)phenyl-
CAS No.:113730-38-4
Molecular Formula:C13H8Cl2O2
Molecular Weight:267.111
Hs Code.:
Mol file:113730-38-4.mol

Synonyms:

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Chemical Property of Methanone, (3,4-dichloro-5-hydroxyphenyl)phenyl-

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Technology Process of Methanone, (3,4-dichloro-5-hydroxyphenyl)phenyl-

There total 6 articles about Methanone, (3,4-dichloro-5-hydroxyphenyl)phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 113730-36-2
3,4-dichloro-5-methoxybenzophenone

: 113730-38-4
3,4-dichloro-5-hydroxybenzophenone

Guidance literature:: With boron tribromide; In dichloromethane; 1.) 5 deg C, 1 h; 2.) room temp., 20 min;
DOI:10.1248/cpb.35.3215

Reference yield:

: 576-24-9
2,3-dichlorophenol

: 113730-38-4
3,4-dichloro-5-hydroxybenzophenone

Guidance literature:: Multi-step reaction with 6 steps

1: 42 percent / HNO₃ / acetic anhydride; acetic acid / 1 h / 4 - 8 °C

2: 97 percent / potassium carbonate / dimethylformamide / 0.67 h / Heating

3: H₂ / Pd-C (10percent) / ethyl acetate

4: 1.) BCl₃, AlCl₃; 2.) HCl (20percent) / 1.) CH₂Cl₂, room temp., 30 min; reflux, 2 h; 2.) 70 deg C, 10 min

5: 1.) NOSO₄H (45percent); 2.) H₃PO₂ / 1.) H₂SO₄, THF, -25 to 0 deg C, 1.5 h; 2.) 6-10 deg C, 2 h

6: 98 percent / BBr₃ / CH₂Cl₂ / 1.) 5 deg C, 1 h; 2.) room temp., 20 min

With hydrogenchloride; aluminium trichloride; nitrosylsulfuric acid; hydrogen; nitric acid; hypophosphorous acid; boron trichloride; boron tribromide; potassium carbonate; palladium on activated charcoal; In dichloromethane; acetic anhydride; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.35.3215

Reference yield:

: 105630-54-4
2,3-dichloro-1-methoxy-4-nitrobenzene

: 113730-38-4
3,4-dichloro-5-hydroxybenzophenone

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd-C (10percent) / ethyl acetate

2: 1.) BCl₃, AlCl₃; 2.) HCl (20percent) / 1.) CH₂Cl₂, room temp., 30 min; reflux, 2 h; 2.) 70 deg C, 10 min

3: 1.) NOSO₄H (45percent); 2.) H₃PO₂ / 1.) H₂SO₄, THF, -25 to 0 deg C, 1.5 h; 2.) 6-10 deg C, 2 h

4: 98 percent / BBr₃ / CH₂Cl₂ / 1.) 5 deg C, 1 h; 2.) room temp., 20 min

With hydrogenchloride; aluminium trichloride; nitrosylsulfuric acid; hydrogen; hypophosphorous acid; boron trichloride; boron tribromide; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1248/cpb.35.3215