Chemical Property of beta-Boswellic acid
Chemical Property:
- Appearance/Colour:Off-White Solid
- Vapor Pressure:1.11E-14mmHg at 25°C
- Melting Point:130-135°C
- Refractive Index:1.555
- Boiling Point:556 °C at 760 mmHg
- PKA:4.50±0.70(Predicted)
- Flash Point:304.1 °C
- PSA：57.53000
- Density:1.09 g/cm3
- LogP:7.08950
- Storage Temp.:-20?C Freezer
- Solubility.:Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- XLogP3:8.3
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:1
- Exact Mass:456.36034539
- Heavy Atom Count:33
- Complexity:878
- Purity/Quality:
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95%-98% *data from raw suppliers
Beta-Boswellic acid *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C(=O)O)O)C)C)C2C1C)C)C
- Isomeric SMILES:C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@H]([C@]5(C)C(=O)O)O)C)C)[C@@H]2[C@H]1C)C)C
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Description
β-Boswellic acid is a pentacyclic triterpene originally isolated from Boswellia that has diverse bioactivities. It inhibits 5-lipoxygenase (5-LO) with an IC50 value of approximately 5 μM but is less potent than its derivative 3-acetyl-11-keto-β-boswellic acid . It inhibits cell proliferation in HL-60 cells with IC50 values of 3.7, 7.1, and 6.3 μM for DNA, RNA, and protein synthesis, respectively. In human umbilical vein endothelial cells (HUVECs) transiently deprived of oxygen and glucose, β-boswellic acid increases nitric oxide and increases phosphorylation of enzyme nitric oxide synthase (eNOS). It also increases calcium mobilization in platelets at concentrations ≥3 μM and induces platelet aggregation (EC50 = 8 μM).
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Uses
The principal constitutents of frankincense (olibanum). A specific, nonredox inhibitor of 5-lipoxygenase used to treat inflammation.
