3'-Adenylic acid, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(diphenylacetyl)-, bis[2-(methylsulfonyl)ethyl] ester

Base Information

• Chemical Name: 3'-Adenylic acid, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(diphenylacetyl)-, bis[2-(methylsulfonyl)ethyl] ester
• CAS No.: 113765-03-0
• Molecular Formula: C₅₁H₅₄N₅O₁₃PS₂
• Molecular Weight: 1040.12
• Mol file: 113765-03-0.mol

Synonyms:

Chemical Property of 3'-Adenylic acid, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(diphenylacetyl)-, bis[2-(methylsulfonyl)ethyl] ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3'-Adenylic acid, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(diphenylacetyl)-, bis[2-(methylsulfonyl)ethyl] ester

There total 3 articles about 3'-Adenylic acid, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-deoxy-N-(diphenylacetyl)-, bis[2-(methylsulfonyl)ethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-diphenylacetylamino-purin-9-yl)-tetrahydro-furan-3-yl ester bis-(2-methanesulfonyl-ethyl) ester (113765-03-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 15 h / Ambient temperature

2: pyridine / 3 h / Ambient temperature

With pyridine;

DOI:10.1016/S0040-4039(00)96203-8

Reference yield:

N6-(diphenylacetyl)-2'-deoxyadenosine (95900-44-0) → Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-diphenylacetylamino-purin-9-yl)-tetrahydro-furan-3-yl ester bis-(2-methanesulfonyl-ethyl) ester (113765-03-0)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 15 h / Ambient temperature

2: pyridine / 3 h / Ambient temperature

With pyridine;

DOI:10.1016/S0040-4039(00)96203-8

Reference yield:

bis<2(methylsulphonyl)ethyl>-phosphochloridate (92483-33-5) + N6-(diphenylacetyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine (95900-43-9) → Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-diphenylacetylamino-purin-9-yl)-tetrahydro-furan-3-yl ester bis-(2-methanesulfonyl-ethyl) ester (113765-03-0)

Guidance literature:

With pyridine; for 3h; Ambient temperature;

DOI:10.1016/S0040-4039(00)96203-8

upstream raw materials:

bis<2(methylsulphonyl)ethyl>-phosphochloridate

N⁶-(diphenylacetyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine

4,4'-dimethoxytrityl chloride

N⁶-(diphenylacetyl)-2'-deoxyadenosine

Downstream raw materials:

Phosphoric acid (2R,3S,5R)-5-(6-diphenylacetylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester bis-(2-methanesulfonyl-ethyl) ester

Phosphoric acid (2R,3S,5R)-2-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxymethyl]-5-(6-diphenylacetylamino-purin-9-yl)-tetrahydro-furan-3-yl ester bis-(2-methanesulfonyl-ethyl) ester