Phosphoric acid (2R,3S,5R)-2-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxymethyl]-5-(6-diphenylacetylamino-purin-9-yl)-tetrahydro-furan-3-yl ester bis-(2-methanesulfonyl-ethyl) ester

Base Information

• Chemical Name: Phosphoric acid (2R,3S,5R)-2-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxymethyl]-5-(6-diphenylacetylamino-purin-9-yl)-tetrahydro-furan-3-yl ester bis-(2-methanesulfonyl-ethyl) ester
• CAS No.: 113784-06-8
• Molecular Formula: C₄₃H₄₆N₈O₁₃P₂S₃
• Molecular Weight: 1041.03
• Mol file: 113784-06-8.mol

Synonyms:

Chemical Property of Phosphoric acid (2R,3S,5R)-2-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxymethyl]-5-(6-diphenylacetylamino-purin-9-yl)-tetrahydro-furan-3-yl ester bis-(2-methanesulfonyl-ethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Phosphoric acid (2R,3S,5R)-2-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxymethyl]-5-(6-diphenylacetylamino-purin-9-yl)-tetrahydro-furan-3-yl ester bis-(2-methanesulfonyl-ethyl) ester

There total 4 articles about Phosphoric acid (2R,3S,5R)-2-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxymethyl]-5-(6-diphenylacetylamino-purin-9-yl)-tetrahydro-furan-3-yl ester bis-(2-methanesulfonyl-ethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N6-(diphenylacetyl)-2'-deoxyadenosine (95900-44-0) → Phosphoric acid (2R,3S,5R)-2-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxymethyl]-5-(6-diphenylacetylamino-purin-9-yl)-tetrahydro-furan-3-yl ester bis-(2-methanesulfonyl-ethyl) ester (113784-06-8)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 15 h / Ambient temperature

2: pyridine / 3 h / Ambient temperature

3: CF₃COOH / CHCl₃ / 0 h / Ambient temperature

4: dioxane / 0.5 h / Ambient temperature

With pyridine; trifluoroacetic acid; In 1,4-dioxane; chloroform;

DOI:10.1016/S0040-4039(00)96203-8

Reference yield:

N6-(diphenylacetyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine (95900-43-9) → Phosphoric acid (2R,3S,5R)-2-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxymethyl]-5-(6-diphenylacetylamino-purin-9-yl)-tetrahydro-furan-3-yl ester bis-(2-methanesulfonyl-ethyl) ester (113784-06-8)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 3 h / Ambient temperature

2: CF₃COOH / CHCl₃ / 0 h / Ambient temperature

3: dioxane / 0.5 h / Ambient temperature

With pyridine; trifluoroacetic acid; In 1,4-dioxane; chloroform;

DOI:10.1016/S0040-4039(00)96203-8

Reference yield:

Phosphoric acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-diphenylacetylamino-purin-9-yl)-tetrahydro-furan-3-yl ester bis-(2-methanesulfonyl-ethyl) ester (113765-03-0) → Phosphoric acid (2R,3S,5R)-2-[(benzotriazol-1-yloxy)-p-tolylsulfanyl-phosphoryloxymethyl]-5-(6-diphenylacetylamino-purin-9-yl)-tetrahydro-furan-3-yl ester bis-(2-methanesulfonyl-ethyl) ester (113784-06-8)

Guidance literature:

Multi-step reaction with 2 steps

1: CF₃COOH / CHCl₃ / 0 h / Ambient temperature

2: dioxane / 0.5 h / Ambient temperature

With trifluoroacetic acid; In 1,4-dioxane; chloroform;

DOI:10.1016/S0040-4039(00)96203-8

upstream raw materials:

S-4-methylphenyl-O,O-bis(1-benzotriazolyl)phosphorothioate

Phosphoric acid (2R,3S,5R)-5-(6-diphenylacetylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester bis-(2-methanesulfonyl-ethyl) ester

N⁶-(diphenylacetyl)-2'-deoxyadenosine

N⁶-(diphenylacetyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxyadenosine