Phenol,3-[8-(butylmethylamino)-1,4-dioxaspiro[4.5]dec-8-yl]-, hydrochloride (9CI)

Base Information

Chemical Name:Phenol,3-[8-(butylmethylamino)-1,4-dioxaspiro[4.5]dec-8-yl]-, hydrochloride (9CI)
CAS No.:65619-90-1
Molecular Formula:C19H29 N O3 . Cl H
Molecular Weight:355.905
Hs Code.:

Synonyms:1,4-Dioxaspiro[4.5]decane,phenol deriv.; MCV 4131; NIH 9468; U 49274A; UM 1152

Suppliers and Price of Phenol,3-[8-(butylmethylamino)-1,4-dioxaspiro[4.5]dec-8-yl]-, hydrochloride (9CI)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Phenol,3-[8-(butylmethylamino)-1,4-dioxaspiro[4.5]dec-8-yl]-, hydrochloride (9CI)

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Phenol,3-[8-(butylmethylamino)-1,4-dioxaspiro[4.5]dec-8-yl]-, hydrochloride (9CI)

There total 9 articles about Phenol,3-[8-(butylmethylamino)-1,4-dioxaspiro[4.5]dec-8-yl]-, hydrochloride (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 65619-89-8
4-(methyl-n-butylamino)-4-(m-benzyloxyphenyl)cyclohexan-1-one, ethylene ketal

: 65619-90-1
4-(N-butyl-N-methylamino)-4-(m-hydroxyphenyl)cyclohexan-1-one ethylene ketal hydrochloride

Guidance literature:: With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethyl acetate; for 24h; Yield given;
DOI:10.1021/jm00135a019

Reference yield:

: 13225-34-8
1-(3-methoxyphenyl)-4-oxocyclohexanecarbonitrile

: 65619-90-1
4-(N-butyl-N-methylamino)-4-(m-hydroxyphenyl)cyclohexan-1-one ethylene ketal hydrochloride

Guidance literature:: Multi-step reaction with 9 steps

1: 93 percent / BBr₃ / CH₂Cl₂ / 4 h

2: 93 percent / p-toluenesulfonic acid (p-TSA) / benzene / 4 h / Heating

3: 1.) NaH / 1.) DMF, C₆H₆, a) RT, 15 min, b) reflux, 1 h, 2.) DMF, C₆H₆, reflux, 4 h

4: 98 percent / NaOH / ethane-1,2-diol / 18 h / Heating

5: 82 percent / Et₃N, (C₆H₅O)2PON₃ / various solvent(s) / 1 h / 90 °C

6: 71 percent / LiAlH₄ / tetrahydrofuran / 5 h / Heating

7: Et₃N / tetrahydrofuran / 7 h / 0 °C

8: LiAlH₄ / tetrahydrofuran / 7 h / Heating

9: H₂, 2 N etheral HCl / 10percent Pd/C / ethyl acetate / 24 h

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; diphenyl phosphoryl azide; hydrogen; boron tribromide; sodium hydride; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethylene glycol; ethyl acetate; benzene;
DOI:10.1021/jm00135a019

Reference yield:

: 65619-83-2
4-cyano-4-(m-hydroxyphenyl)cyclohexanone

: 65619-90-1
4-(N-butyl-N-methylamino)-4-(m-hydroxyphenyl)cyclohexan-1-one ethylene ketal hydrochloride

Guidance literature:: Multi-step reaction with 8 steps

1: 93 percent / p-toluenesulfonic acid (p-TSA) / benzene / 4 h / Heating

2: 1.) NaH / 1.) DMF, C₆H₆, a) RT, 15 min, b) reflux, 1 h, 2.) DMF, C₆H₆, reflux, 4 h

3: 98 percent / NaOH / ethane-1,2-diol / 18 h / Heating

4: 82 percent / Et₃N, (C₆H₅O)2PON₃ / various solvent(s) / 1 h / 90 °C

5: 71 percent / LiAlH₄ / tetrahydrofuran / 5 h / Heating

6: Et₃N / tetrahydrofuran / 7 h / 0 °C

7: LiAlH₄ / tetrahydrofuran / 7 h / Heating

8: H₂, 2 N etheral HCl / 10percent Pd/C / ethyl acetate / 24 h

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; diphenyl phosphoryl azide; hydrogen; sodium hydride; toluene-4-sulfonic acid; triethylamine; palladium on activated charcoal; In tetrahydrofuran; ethylene glycol; ethyl acetate; benzene;
DOI:10.1021/jm00135a019