Technology Process of D-Valine,
N-[S-(diphenylmethyl)-N-[[3-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenoxy]
acetyl]-L-cysteinyl]-, diphenylmethyl ester
There total 12 articles about D-Valine,
N-[S-(diphenylmethyl)-N-[[3-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenoxy]
acetyl]-L-cysteinyl]-, diphenylmethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 88 percent / sodium hydride (50percent oil dispersion) / dimethylformamide / 2 h / 20 °C
2: 1) BuLi, / 1) THF, -78 deg C, 1h, 2) THF, -78 deg C, 1h
3: 99 percent / hydroxylamine hydrochloride / pyridine; ethanol / 4 h / Heating
4: 85 percent / pyridine / 2 h / Heating
5: 73 percent / NH3 / diethyl ether / 8 h / -78 °C
6: Ag2O / diethyl ether / 3 h / in the dark
7: 54 percent / glacial acetic acid, 2M HCl / 3 h / in the dark
8: 100 percent / potassium carbonate / acetone / Ambient temperature; protection from light
With
pyridine; hydrogenchloride; n-butyllithium; hydroxylamine hydrochloride; ammonia; sodium hydride; potassium carbonate; acetic acid; silver(l) oxide;
In
pyridine; diethyl ether; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4020(01)81664-1
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1) BuLi, / 1) THF, -78 deg C, 1h, 2) THF, -78 deg C, 1h
2: 99 percent / hydroxylamine hydrochloride / pyridine; ethanol / 4 h / Heating
3: 85 percent / pyridine / 2 h / Heating
4: 73 percent / NH3 / diethyl ether / 8 h / -78 °C
5: Ag2O / diethyl ether / 3 h / in the dark
6: 54 percent / glacial acetic acid, 2M HCl / 3 h / in the dark
7: 100 percent / potassium carbonate / acetone / Ambient temperature; protection from light
With
pyridine; hydrogenchloride; n-butyllithium; hydroxylamine hydrochloride; ammonia; potassium carbonate; acetic acid; silver(l) oxide;
In
pyridine; diethyl ether; ethanol; acetone;
DOI:10.1016/S0040-4020(01)81664-1
