3-Quinolinecarboxylic acid, 6,7,8-trifluoro-1-(4-fluorophenyl)-1,4-dihydro-5-(4-methyl-1-piperazinyl)- 4-oxo-, ethyl ester

Base Information

• Chemical Name: 3-Quinolinecarboxylic acid, 6,7,8-trifluoro-1-(4-fluorophenyl)-1,4-dihydro-5-(4-methyl-1-piperazinyl)- 4-oxo-, ethyl ester
• CAS No.: 113846-25-6
• Molecular Formula: C₂₃H₂₁F₄N₃O₃
• Molecular Weight: 463.432
• Mol file: 113846-25-6.mol

Synonyms:

Chemical Property of 3-Quinolinecarboxylic acid, 6,7,8-trifluoro-1-(4-fluorophenyl)-1,4-dihydro-5-(4-methyl-1-piperazinyl)- 4-oxo-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Quinolinecarboxylic acid, 6,7,8-trifluoro-1-(4-fluorophenyl)-1,4-dihydro-5-(4-methyl-1-piperazinyl)- 4-oxo-, ethyl ester

There total 3 articles about 3-Quinolinecarboxylic acid, 6,7,8-trifluoro-1-(4-fluorophenyl)-1,4-dihydro-5-(4-methyl-1-piperazinyl)- 4-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1-methyl-piperazine (109-01-3) + 5,6,7,8-Tetrafluoro-1-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (107564-03-4) → 6,7,8-Trifluoro-1-(4-fluoro-phenyl)-5-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (113846-25-6)

Guidance literature:

With pyridine; steam bath;

DOI:10.1021/jm00126a028

Reference yield:

ethyl-2-ethoxymethylene-3-oxo-3-pentafluorophenylpropionate (114226-95-8) → 6,7,8-Trifluoro-1-(4-fluoro-phenyl)-5-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (113846-25-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / ethanol / 0 deg C to r.t., 18 h

2: 99 percent / potassium carbonate / dimethylformamide / 25 °C

3: 74 percent / pyridine / steam bath

With pyridine; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00126a028

Reference yield:

4-fluoroaniline (371-40-4) → 6,7,8-Trifluoro-1-(4-fluoro-phenyl)-5-(4-methyl-piperazin-1-yl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (113846-25-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / ethanol / 0 deg C to r.t., 18 h

2: 99 percent / potassium carbonate / dimethylformamide / 25 °C

3: 74 percent / pyridine / steam bath

With pyridine; potassium carbonate; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00126a028

upstream raw materials:

1-methyl-piperazine

5,6,7,8-Tetrafluoro-1-(4-fluoro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester

ethyl-2-ethoxymethylene-3-oxo-3-pentafluorophenylpropionate

4-fluoroaniline