L-Tyrosine, N-[N-[(1,1-dimethylethoxy)carbonyl]-S-(phenylmethyl)-L-cysteinyl]-, hydrazide

Base Information

• Chemical Name: L-Tyrosine, N-[N-[(1,1-dimethylethoxy)carbonyl]-S-(phenylmethyl)-L-cysteinyl]-, hydrazide
• CAS No.: 113847-15-7
• Molecular Formula: C24H32N4O5S
• Molecular Weight: 488.608
• Mol file: 113847-15-7.mol

Synonyms:

Chemical Property of L-Tyrosine, N-[N-[(1,1-dimethylethoxy)carbonyl]-S-(phenylmethyl)-L-cysteinyl]-, hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Tyrosine, N-[N-[(1,1-dimethylethoxy)carbonyl]-S-(phenylmethyl)-L-cysteinyl]-, hydrazide

There total 3 articles about L-Tyrosine, N-[N-[(1,1-dimethylethoxy)carbonyl]-S-(phenylmethyl)-L-cysteinyl]-, hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

Boc-Cys(Bzl)-Tyr-OMe (56618-60-1) → BOCCys(Bzl)TyrN2H3 (113847-15-7)

Guidance literature:

With hydrazine hydrate; In methanol; at 0 ℃; for 18h;

DOI:10.1007/BF00596712

Reference yield:

(2R)-3-benzylsulfanyl-2-tert-butoxycarbonylamino-propionic acid (5068-28-0) → BOCCys(Bzl)TyrN2H3 (113847-15-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / ethyl chloroformate, TEA / CHCl₃; various solvent(s) / 1) -2 deg C, 2h, 2) 0 deg C, 18 h

2: 74 percent / hydrazine hydrate / methanol / 18 h / 0 °C

With TEA; chloroformic acid ethyl ester; hydrazine hydrate; In methanol; chloroform;

DOI:10.1007/BF00596712

Reference yield:

L-Tyr-OMe (1080-06-4) → BOCCys(Bzl)TyrN2H3 (113847-15-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / ethyl chloroformate, TEA / CHCl₃; various solvent(s) / 1) -2 deg C, 2h, 2) 0 deg C, 18 h

2: 74 percent / hydrazine hydrate / methanol / 18 h / 0 °C

With TEA; chloroformic acid ethyl ester; hydrazine hydrate; In methanol; chloroform;

DOI:10.1007/BF00596712

upstream raw materials:

Boc-Cys(Bzl)-Tyr-OMe

(2R)-3-benzylsulfanyl-2-tert-butoxycarbonylamino-propionic acid

L-Tyr-OMe

Refernces