3-(Chloromethyl)imidazo[1,2-a]pyridine

Base Information

• Chemical Name: 3-(Chloromethyl)imidazo[1,2-a]pyridine
• CAS No.: 113855-44-0
• Molecular Formula: C8H7ClN2
• Molecular Weight: 166.60800
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID40406603
• Wikidata: Q72454101
• Mol file: 113855-44-0.mol

Synonyms:3-(chloromethyl)imidazo[1,2-a]pyridine;113855-44-0;3-Chloromethylimidazo[1,2-a]pyridine;3-Chloromethyl-imidazo[1,2-a]pyridine;3-(CHLOROMETHYL)H-IMIDAZO[1,2-A]PYRIDINE;SCHEMBL5755912;DTXSID40406603;AKOS006242087;AB23751;CS-0441052;FT-0685493;EN300-1981876;W-204825

Chemical Property of 3-(Chloromethyl)imidazo[1,2-a]pyridine

Chemical Property:

• PKA: 5.97±0.50(Predicted)
• PSA: 17.30000
• Density: 1.29g/cm3
• LogP: 2.07310
• Storage Temp.: 2-8°C
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 166.0297759
• Heavy Atom Count: 11
• Complexity: 140

Purity/Quality:

98%min ^*data from raw suppliers

3-Chloromethylimidazo[1,2-a]pyridine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC2=NC=C(N2C=C1)CCl

Technology Process of 3-(Chloromethyl)imidazo[1,2-a]pyridine

There total 5 articles about 3-(Chloromethyl)imidazo[1,2-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-hydroxymethylimidazo[1,2-a]pyridine (30489-43-1) → 3-chloromethylimidazo[1,2-a]pyridine (113855-44-0)

Guidance literature:

With thionyl chloride; Heating;

DOI:10.1021/jm9507901

Reference yield:

imidazo[1,2-a]pyridine (274-76-0) → 3-chloromethylimidazo[1,2-a]pyridine (113855-44-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 30 percent / POCl₃

2: NaBH₄ / methanol

3: SOCl₂ / Heating

With sodium tetrahydroborate; thionyl chloride; trichlorophosphate; In methanol;

DOI:10.1021/jm9507901

Reference yield:

2-aminopyridine (504-29-0) → 3-chloromethylimidazo[1,2-a]pyridine (113855-44-0)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol / Heating

2: 30 percent / POCl₃

3: NaBH₄ / methanol

4: SOCl₂ / Heating

With sodium tetrahydroborate; thionyl chloride; trichlorophosphate; In methanol; ethanol;

DOI:10.1021/jm9507901

upstream raw materials:

3-hydroxymethylimidazo[1,2-a]pyridine

2-aminopyridine

imidazo[1,2-a]pyridine

imidazo[1,2-a]pyridine-3-carbaldehyde

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