Pyrido[2,3-d]pyrimidine-6-methanol, 2,4-diamino-7-methyl-5-phenyl-, monohydrochloride

Base Information

Chemical Name:Pyrido[2,3-d]pyrimidine-6-methanol, 2,4-diamino-7-methyl-5-phenyl-, monohydrochloride
CAS No.:113859-31-7
Molecular Formula:C15H15N5O.ClH
Molecular Weight:317.778
Hs Code.:
Mol file:113859-31-7.mol

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Pyrido[2,3-d]pyrimidine-6-methanol, 2,4-diamino-7-methyl-5-phenyl-, monohydrochloride

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Technology Process of Pyrido[2,3-d]pyrimidine-6-methanol, 2,4-diamino-7-methyl-5-phenyl-, monohydrochloride

There total 7 articles about Pyrido[2,3-d]pyrimidine-6-methanol, 2,4-diamino-7-methyl-5-phenyl-, monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 113859-25-9
6-Methoxymethoxymethyl-7-methyl-5-phenyl-pyrido[2,3-d]pyrimidine-2,4-diamine

: 113859-31-7
(2,4-Diamino-7-methyl-5-phenyl-pyrido[2,3-d]pyrimidin-6-yl)-methanol; hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; for 4h; Heating;
DOI:10.1021/jm00401a023

Reference yield:

: 569-37-9
ethyl 3-oxo-2-benzoylbutanoate

: 113859-31-7
(2,4-Diamino-7-methyl-5-phenyl-pyrido[2,3-d]pyrimidin-6-yl)-methanol; hydrochloride

Guidance literature:: Multi-step reaction with 7 steps

1: 4.2 percent / piperidine / ethanol / 1.) room temperature, 1 d, 2.) reflux, 1 d

2: 92 percent / K₂CO₃ / dimethylformamide / Ambient temperature

3: 58 percent / LiAlH₄ / diethyl ether / 3 h / -10 °C

4: 81 percent / N,N-dimethylaniline / CHCl₃ / 5 h / Ambient temperature

5: 96 percent / m-CPBA / ethanol / 1 h / Ambient temperature

6: 53 percent / diphenyl ether / 2 h / 180 - 185 °C

7: 40 percent / HCl / methanol / 4 h / Heating

With piperidine; hydrogenchloride; lithium aluminium tetrahydride; potassium carbonate; N,N-dimethyl-aniline; 3-chloro-benzenecarboperoxoic acid; In methanol; diphenylether; diethyl ether; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00401a023

Reference yield:

: 97651-26-8
3-cyano-5-(ethoxycarbonyl)-6-methyl-4-phenylpyridine-2(1H)-thione

: 113859-31-7
(2,4-Diamino-7-methyl-5-phenyl-pyrido[2,3-d]pyrimidin-6-yl)-methanol; hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / K₂CO₃ / dimethylformamide / Ambient temperature

2: 58 percent / LiAlH₄ / diethyl ether / 3 h / -10 °C

3: 81 percent / N,N-dimethylaniline / CHCl₃ / 5 h / Ambient temperature

4: 96 percent / m-CPBA / ethanol / 1 h / Ambient temperature

5: 53 percent / diphenyl ether / 2 h / 180 - 185 °C

6: 40 percent / HCl / methanol / 4 h / Heating

With hydrogenchloride; lithium aluminium tetrahydride; potassium carbonate; N,N-dimethyl-aniline; 3-chloro-benzenecarboperoxoic acid; In methanol; diphenylether; diethyl ether; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00401a023