L-Glutamic acid, N-[4-[[(2,4-diamino-5-methyl-7-phenylpyrido[2,3-d]pyrimidin-6-yl)methyl] amino]benzoyl]-, diethyl ester

Base Information

Chemical Name:L-Glutamic acid, N-[4-[[(2,4-diamino-5-methyl-7-phenylpyrido[2,3-d]pyrimidin-6-yl)methyl] amino]benzoyl]-, diethyl ester
CAS No.:113859-35-1
Molecular Formula:C31H35N7O5
Molecular Weight:585.663
Hs Code.:
Mol file:113859-35-1.mol

Synonyms:

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Chemical Property of L-Glutamic acid, N-[4-[[(2,4-diamino-5-methyl-7-phenylpyrido[2,3-d]pyrimidin-6-yl)methyl] amino]benzoyl]-, diethyl ester

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Technology Process of L-Glutamic acid, N-[4-[[(2,4-diamino-5-methyl-7-phenylpyrido[2,3-d]pyrimidin-6-yl)methyl] amino]benzoyl]-, diethyl ester

There total 9 articles about L-Glutamic acid, N-[4-[[(2,4-diamino-5-methyl-7-phenylpyrido[2,3-d]pyrimidin-6-yl)methyl] amino]benzoyl]-, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 569-37-9
ethyl 3-oxo-2-benzoylbutanoate

: 113859-35-1
diethyl N-pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 9 steps

1: 16.4 percent / piperidine / ethanol / 1.) room temperature, 1 d, 2.) reflux, 1 d

2: 90 percent / K₂CO₃ / dimethylformamide / Ambient temperature

3: 47 percent / LiAlH₄ / diethyl ether / 3 h / -10 °C

4: 82 percent / N,N-dimethylaniline / CHCl₃ / 5 h / Ambient temperature

5: 94 percent / m-CPBA / ethanol / 1 h / Ambient temperature

6: 75 percent / diphenyl ether / 2 h / 180 - 185 °C

7: 62 percent / conc. HCl / methanol / 4 h / Heating

8: HBr / dioxane / Ambient temperature

9: N,N-dimethylacetamide / 72 h / Ambient temperature

With piperidine; hydrogenchloride; lithium aluminium tetrahydride; N,N-dimethyl acetamide; hydrogen bromide; potassium carbonate; N,N-dimethyl-aniline; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; methanol; diphenylether; diethyl ether; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00401a023

Reference yield:

: 113859-06-6
5-Hydroxymethyl-4-methyl-2-methylsulfanyl-6-phenyl-nicotinonitrile

: 113859-35-1
diethyl N-pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / N,N-dimethylaniline / CHCl₃ / 5 h / Ambient temperature

2: 94 percent / m-CPBA / ethanol / 1 h / Ambient temperature

3: 75 percent / diphenyl ether / 2 h / 180 - 185 °C

4: 62 percent / conc. HCl / methanol / 4 h / Heating

5: HBr / dioxane / Ambient temperature

6: N,N-dimethylacetamide / 72 h / Ambient temperature

With hydrogenchloride; N,N-dimethyl acetamide; hydrogen bromide; N,N-dimethyl-aniline; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; methanol; diphenylether; ethanol; chloroform;
DOI:10.1021/jm00401a023

Reference yield:

: 113858-95-0
3-cyano-5-(ethoxycarbonyl)-4-methyl-6-phenylpyridine-2(1H)-thione

: 113859-35-1
diethyl N-pyrimidin-6-yl)methyl>amino>benzoyl>-L-glutamate

Guidance literature:: Multi-step reaction with 8 steps

1: 90 percent / K₂CO₃ / dimethylformamide / Ambient temperature

2: 47 percent / LiAlH₄ / diethyl ether / 3 h / -10 °C

3: 82 percent / N,N-dimethylaniline / CHCl₃ / 5 h / Ambient temperature

4: 94 percent / m-CPBA / ethanol / 1 h / Ambient temperature

5: 75 percent / diphenyl ether / 2 h / 180 - 185 °C

6: 62 percent / conc. HCl / methanol / 4 h / Heating

7: HBr / dioxane / Ambient temperature

8: N,N-dimethylacetamide / 72 h / Ambient temperature

With hydrogenchloride; lithium aluminium tetrahydride; N,N-dimethyl acetamide; hydrogen bromide; potassium carbonate; N,N-dimethyl-aniline; 3-chloro-benzenecarboperoxoic acid; In 1,4-dioxane; methanol; diphenylether; diethyl ether; ethanol; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm00401a023