3-[(3-AMINO-3-OXOPROPYL)DITHIO]PROPANAMIDE

Base Information

• Chemical Name: 3-[(3-AMINO-3-OXOPROPYL)DITHIO]PROPANAMIDE
• CAS No.: 1002-19-3
• Molecular Formula: C6H12N2O2S2
• Molecular Weight: 208.305
• Hs Code.: 2930909090
• Mol file: 1002-19-3.mol

Synonyms:Propionamide,3,3'-dithiobis- (7CI,8CI);3,3'-Dithiodipropionamide;b,b'-Dipropionamidedisulfide;

Chemical Property of 3-[(3-AMINO-3-OXOPROPYL)DITHIO]PROPANAMIDE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 178-180 °C(Solv: ethanol (64-17-5))
• Boiling Point: 526 °C at 760 mmHg
• PKA: 15.86±0.40(Predicted)
• Flash Point: 271.9 °C
• PSA: 136.78000
• Density: 1.325 g/cm³
• LogP: 1.51920
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-[(3-Amino-3-oxopropyl)disulfanyl]propanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-[(3-AMINO-3-OXOPROPYL)DITHIO]PROPANAMIDE

There total 10 articles about 3-[(3-AMINO-3-OXOPROPYL)DITHIO]PROPANAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.2%

3,3'-dithiobis(propionic acid) (1119-62-6) → 3,3'-disulfanediylpropanamide (1002-19-3)

Guidance literature:

3,3'-dithiobis(propionic acid); With thionyl chloride; for 1h; Reflux;

With ammonium hydroxide; Cooling with ice;

Reference yield: 80.0%

3-(2-chlorocarbonyl-ethyldisulfanyl)-propionyl chloride (1002-18-2) → 3,3'-disulfanediylpropanamide (1002-19-3)

Guidance literature:

With ammonia; In dichloromethane;

DOI:10.1016/j.ejmech.2004.04.004

Reference yield: 31.0%

3-(benzhydrylthio)propanamide (135468-50-7) → 3,3'-disulfanediylpropanamide (1002-19-3)

Guidance literature:

With ammonia; sodium; ammonium chloride;

DOI:10.1021/ja00016a031

upstream raw materials:

carbon disulfide

β-Propiothiolactone

3,3'-dithiobis(propionic acid)

3-(2-chlorocarbonyl-ethyldisulfanyl)-propionyl chloride

Downstream raw materials:

5-chloroisothiazol-3(2H)-one

3-oxo-2,3-dihydroisothiazole

3-Chlorisothiazol

β-mercaptopropionamide

Refernces

• 1、 Schwab, Joseph J.,Wilkinson, Elizabeth C.,Wilson, Scott R.,Shapley, Patricia A.. "Nitridoosmium(VI) and nitridoruthenium(VI) complexes of cysteine(2-) and related ligands". . p. 6124 - 6129. Retrieved 1991.
• 2、 -. "A 3 - chloroisothiazole chemical synthesis method". Paragraph 0016; 0017. . Retrieved 2018/02/22.
• 3、 Beeley, Nigel R. A.,Harwood, Laurence M.,Hedger, Paul C.. "A General Synthesis of N-Substituted Isothiazol-3(2H)-ones". . p. 2245 - 2252. Retrieved 2007/10/02.