3,3'-Disulfanediyldipropanoyl chloride

Base Information

• Chemical Name: 3,3'-Disulfanediyldipropanoyl chloride
• CAS No.: 1002-18-2
• Molecular Formula: C6H8Cl2O2S2
• Molecular Weight: 247.166
• European Community (EC) Number: 600-037-8
• DSSTox Substance ID: DTXSID601298375
• Nikkaji Number: J2.513.353F
• Mol file: 1002-18-2.mol

Synonyms:1002-18-2;3,3'-Disulfanediyldipropanoyl chloride;3-[(3-CHLORO-3-OXOPROPYL)DISULFANYL]PROPANOYL CHLORIDE;Propanoyl chloride, 3,3'-dithiobis-;3,3/'-disulfanediyldipropanoyl chloride;3,3'-disulfanediyldipropionyl chloride;dithiodipropionyl chloride;SCHEMBL1013197;DTXSID601298375;3,3'-Dithiobis[propanoyl chloride];3,3'-Disulfanediyldipropanoylchloride;3,3'-dithiodipropionic acid chloride;3,3'-Dithiobis(propanoic acid chloride);J-511095

Chemical Property of 3,3'-Disulfanediyldipropanoyl chloride

Chemical Property:

• Boiling Point: 130-150 °C(Press: 0.001 Torr)
• Flash Point: 149.4oC
• PSA: 84.74000
• Density: 1.432±0.06 g/cm3(Predicted)
• LogP: 2.67880
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 245.9342772
• Heavy Atom Count: 12
• Complexity: 146

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CSSCCC(=O)Cl)C(=O)Cl

Technology Process of 3,3'-Disulfanediyldipropanoyl chloride

There total 1 articles about 3,3'-Disulfanediyldipropanoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3-(acetylthio)propanoyl chloride (41345-72-6) → 3-(2-chlorocarbonyl-ethyldisulfanyl)-propionyl chloride (1002-18-2)

Guidance literature:

With sulfuryl dichloride; at 25 ℃; for 1h;

DOI:10.1007/BF00953096

Reference yield: 95.0%

3-(2-chlorocarbonyl-ethyldisulfanyl)-propionyl chloride (1002-18-2) + methyl 2-amino-3-phenylpropanoate hydrochloride (5619-07-8) → 2-[3-[2-(1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-ethyldisulfanyl]propionylamino]-3-phenyl-propionic acid methyl ester

Guidance literature:

With triethylamine; In dichloromethane; 1,2-dichloro-ethane; at 5 - 15 ℃; for 4h;

DOI:10.1016/j.tet.2003.09.064

Reference yield: 94.0%

3-(2-chlorocarbonyl-ethyldisulfanyl)-propionyl chloride (1002-18-2) + 4-amino-2-trifluoromethylbenzonitrile (654-70-6) → 3,3'-disulfanediylbis(N-(4-cyano-3-(trifluoromethyl)phenyl)propanamide) (1011526-76-3)

Guidance literature:

In tetrahydrofuran; at 22 - 55 ℃; for 0.833333h;

upstream raw materials:

3-(acetylthio)propanoyl chloride

Downstream raw materials:

N,N'-bis-(2,5-dichloro-phenyl)-3,3'-disulfanediyl-bis-propionamide

3,3'-disulfanediylbis(N-octylpropanamide)

3,3'-disulfanediylpropanamide

N,N'-bis-(2,4-dichloro-phenyl)-3,3'-disulfanediyl-bis-propionamide

Refernces