2-Ethoxybenzhydrazide

Base Information

• Chemical Name: 2-Ethoxybenzhydrazide
• CAS No.: 21018-13-3
• Molecular Formula: C9H12N2O2
• Molecular Weight: 180.206
• Hs Code.: 2928000090
• European Community (EC) Number: 674-235-8
• DSSTox Substance ID: DTXSID40175226
• Wikidata: Q72471300
• Mol file: 21018-13-3.mol

Synonyms:2-Ethoxybenzhydrazide;2-Ethoxybenzohydrazide;21018-13-3;o-Ethoxy benzhydrazide;2-ethoxybenzoyl hydrazine;benzoic acid, 2-ethoxy-, hydrazide;2-ethoxybenzoylhydrazine;2-Ethoxybenzohydrazide #;18233-18-6;SCHEMBL2358299;DTXSID40175226;2-ethoxybenzhydrazide, AldrichCPR;MFCD00017050;STL377869;AKOS000149352;SB85942;AS-10849;CS-0113628;FT-0638074;D71108;A815078;J-509305

Chemical Property of 2-Ethoxybenzhydrazide

Chemical Property:

• Appearance/Colour: white to pale yellow crystalline powder
• Melting Point: 62-64 °C
• Refractive Index: 1.549
• PKA: 12.46±0.10(Predicted)
• PSA: 64.35000
• Density: 1.144 g/cm³
• LogP: 1.78000
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 180.089877630
• Heavy Atom Count: 13
• Complexity: 173

Purity/Quality:

97% ^*data from raw suppliers

2-Ethoxybenzhydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=CC=C1C(=O)NN

Technology Process of 2-Ethoxybenzhydrazide

There total 5 articles about 2-Ethoxybenzhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-ethoxybenzoic acid (134-11-2) → 2-ethoxybenzoic acid hydrazide (21018-13-3)

Guidance literature:

2-ethoxybenzoic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h; Inert atmosphere;

With hydrazine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1002/cmdc.201900618

Reference yield:

ethyl 2-ethoxybenzoate (6290-24-0) → 2-ethoxybenzoic acid hydrazide (21018-13-3)

Guidance literature:

With hydrazine hydrate; In ethanol; cyclohexane;

Reference yield:

C12H12N2O2 → 2-ethoxybenzoic acid hydrazide (21018-13-3)

Guidance literature:

With hydrazine hydrate; for 0.0333333h; Sonication;

upstream raw materials:

ethyl 2-ethoxybenzoate

methyl 2-ethoxybenzoate

2-ethoxybenzoic acid

Downstream raw materials:

5-(2-ethoxy-phenyl)-3H-[1,3,4]oxadiazol-2-one

2-(o.etossifenil)-5-mercapto-1,3,4-oxadiazolo

2-(2-ethoxy-phenyl)-5-methyl-[1,3,4]oxadiazole

2-(2-ethoxy-phenyl)-5-phenyl-[1,3,4]oxadiazole