5-Ethyl-4-{[(4-methoxyphenyl)methoxy]methyl}oxolane-2,3-diol

Base Information

Chemical Name:5-Ethyl-4-{[(4-methoxyphenyl)methoxy]methyl}oxolane-2,3-diol
CAS No.:113956-97-1
Molecular Formula:C15H22O5
Molecular Weight:282.337
Hs Code.:
DSSTox Substance ID:DTXSID90550488

Synonyms:113956-97-1;DTXSID90550488;5-Ethyl-4-{[(4-methoxyphenyl)methoxy]methyl}oxolane-2,3-diol

Suppliers and Price of 5-Ethyl-4-{[(4-methoxyphenyl)methoxy]methyl}oxolane-2,3-diol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 5-Ethyl-4-{[(4-methoxyphenyl)methoxy]methyl}oxolane-2,3-diol

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:6
Exact Mass:282.14672380
Heavy Atom Count:20
Complexity:277

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1C(C(C(O1)O)O)COCC2=CC=C(C=C2)OC

Technology Process of 5-Ethyl-4-{[(4-methoxyphenyl)methoxy]methyl}oxolane-2,3-diol

There total 5 articles about 5-Ethyl-4-{[(4-methoxyphenyl)methoxy]methyl}oxolane-2,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 108470-15-1
1,2-O-isopropylidene-3-C-(4-methoxybenzyl)oxymethyl-3,5,6-trideoxy-α-D-ribo-hexofuranose

: 113956-97-1
3-C-(4-methoxybenzyl)oxymethyl-3,5,6-trideoxy-α-D-ribo-hexofuranose

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; at 50 ℃; for 5.5h;
DOI:10.1248/cpb.35.2219

Reference yield:

: 98039-10-2
3-deoxy-1,2,5,6-di-O-isopropylidene-3-C-(4-metoxybenzyloxymethyl)-α-D-allofuranose

: 113956-97-1
3-C-(4-methoxybenzyl)oxymethyl-3,5,6-trideoxy-α-D-ribo-hexofuranose

Guidance literature:: Multi-step reaction with 5 steps

1: 86.5 percent / 2percent H₂SO₄ / methanol / 15 h / Ambient temperature

2: Et₃N/DMAP / CH₂Cl₂ / 19 h / Ambient temperature

3: NaI / butan-2-one / 24 h / Heating

4: 98.5 percent / H₂ / 10percent Pd-C / 0.5 h

5: 70 percent / 4.5 N HCl / tetrahydrofuran / 5.5 h / 50 °C

With hydrogenchloride; dmap; sulfuric acid; hydrogen; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; butanone;
DOI:10.1248/cpb.35.2219

Reference yield:

: 86654-47-9
(R)-1-[(3aR,5S,6R,6aR)-6-(4-Methoxy-benzyloxymethyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-ethane-1,2-diol

: 113956-97-1
3-C-(4-methoxybenzyl)oxymethyl-3,5,6-trideoxy-α-D-ribo-hexofuranose

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N/DMAP / CH₂Cl₂ / 19 h / Ambient temperature

2: NaI / butan-2-one / 24 h / Heating

3: 98.5 percent / H₂ / 10percent Pd-C / 0.5 h

4: 70 percent / 4.5 N HCl / tetrahydrofuran / 5.5 h / 50 °C

With hydrogenchloride; dmap; hydrogen; triethylamine; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; butanone;
DOI:10.1248/cpb.35.2219