9-(3-hydroxypropoxy)guanine

Base Information

• Chemical Name: 9-(3-hydroxypropoxy)guanine
• CAS No.: 114778-60-8
• Molecular Formula: C8H11 N5 O3
• Molecular Weight: 225.207
• Mol file: 114778-60-8.mol

Synonyms:9-(3-Hydroxypropoxy)guanine;BRL 44385

Chemical Property of 9-(3-hydroxypropoxy)guanine

Chemical Property:

• Vapor Pressure: 1.2E-12mmHg at 25°C
• Boiling Point: 543.6°Cat760mmHg
• PKA: 9.32±0.20(Predicted)
• Flash Point: 282.5°C
• PSA: 120.04000
• Density: 1.77g/cm³
• LogP: -1.14480

Purity/Quality:

99% ^*data from raw suppliers

9-(3-HYDROXYPROPOXY)GUANINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 9-(3-hydroxypropoxy)guanine

There total 13 articles about 9-(3-hydroxypropoxy)guanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

9-(3-benzyloxypropoxy)guanine (114778-89-1) → 9-(3-hydroxypropoxy)guanine (114778-60-8)

Guidance literature:

With hydrogen; palladium on activated charcoal; In formic acid;

DOI:10.1016/S0040-4039(00)80188-4

Reference yield: 60.0%

2-[(bis-t-butoxycarbonyl)amino]-9-(3-t-butyldimethylsilyloxyprop-1-oxy)-6-methoxypurine (129415-96-9) → 9-(3-hydroxypropoxy)guanine (114778-60-8)

Guidance literature:

With hydrogenchloride; In ethanol; Heating;

DOI:10.1016/0040-4039(90)80104-T

Reference yield: 58.0%

9-<3-<(tert-butyldimethylsilyl)oxy>propoxy>-6-chloro-2-formamidopurine (114778-48-2) → 9-(3-hydroxypropoxy)guanine (114778-60-8)

Guidance literature:

With ammonium hydroxide; formic acid; 1.) 100 deg C, 1 h, 2.) RT, 1 h;

DOI:10.1021/jm00163a031

upstream raw materials:

9-<3-<(tert-butyldimethylsilyl)oxy>propoxy>-6-chloro-2-formamidopurine

2-[(bis-t-butoxycarbonyl)amino]-9-(3-t-butyldimethylsilyloxyprop-1-oxy)-6-methoxypurine

9-(3-benzyloxypropoxy)guanine

4,6-dichloro-2,5-diformamido-pyrimidine

Downstream raw materials:

9-(3-hexanoyloxyprop-1-oxy)guanine

9-(3-benzoyloxyprop-1-oxy)guanine

Refernces

• 1、 Harnden, M. R.,Wyatt, P. G.. "SYNTHESIS OF 9-HYDROXYPURINES: INTERMEDIATES TO NOVEL ANTIVIRAL ACYCLONUCLEOSIDES". . p. 2185 - 2188. Retrieved 2007/10/02.
• 2、 Harnden, M. R.,Parkin, A.,Wyatt, P. G.. "SYNTHESIS OF 9-(3-HYDROXYPROPOXY)GUANINE, A NOVEL ANTIVIRAL ACYCLONUCLEOSIDE". . p. 701 - 704. Retrieved 2007/10/02.