Technology Process of 3-[(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)oxy]propyl benzoate
There total 3 articles about 3-[(2-amino-6-oxo-3,6-dihydro-9H-purin-9-yl)oxy]propyl benzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
dmap;
In
N,N-dimethyl-formamide;
for 2h;
Ambient temperature;
DOI:10.1021/jm00163a031
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 67 percent / diisopropylethylamine / bis-(2-methoxy-ethyl) ether / 3 h / 100 °C
2: 81 percent / various solvent(s) / 1.5 h / 120 °C
3: 58 percent / 1.) 80percent formic acid, 2.) aq NH3 / 1.) 100 deg C, 1 h, 2.) RT, 1 h
4: 36 percent / 4-(dimethylamino)pyridine / dimethylformamide / 2 h / Ambient temperature
With
dmap; ammonium hydroxide; formic acid; N-ethyl-N,N-diisopropylamine;
In
diethylene glycol dimethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm00163a031
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 58 percent / 1.) 80percent formic acid, 2.) aq NH3 / 1.) 100 deg C, 1 h, 2.) RT, 1 h
2: 36 percent / 4-(dimethylamino)pyridine / dimethylformamide / 2 h / Ambient temperature
With
dmap; ammonium hydroxide; formic acid;
In
N,N-dimethyl-formamide;
DOI:10.1021/jm00163a031
