3,5-Bis{[tert-butyl(dimethyl)silyl]oxy}-2-fluorobenzaldehyde

Base Information

Chemical Name:3,5-Bis{[tert-butyl(dimethyl)silyl]oxy}-2-fluorobenzaldehyde
CAS No.:113984-64-8
Molecular Formula:C19H33FO3Si2
Molecular Weight:384.639
Hs Code.:
DSSTox Substance ID:DTXSID50551390
Wikidata:Q82431029
Mol file:113984-64-8.mol

Synonyms:113984-64-8;SCHEMBL5882957;DTXSID50551390;YVZZVIXBGZRDAY-UHFFFAOYSA-N;3,5-Bis{[tert-butyl(dimethyl)silyl]oxy}-2-fluorobenzaldehyde;3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-fluoro-benzaldehyde

Suppliers and Price of 3,5-Bis{[tert-butyl(dimethyl)silyl]oxy}-2-fluorobenzaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3,5-Bis{[tert-butyl(dimethyl)silyl]oxy}-2-fluorobenzaldehyde

Chemical Property:

Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:384.19522614
Heavy Atom Count:25
Complexity:466

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)[Si](C)(C)OC1=CC(=C(C(=C1)O[Si](C)(C)C(C)(C)C)F)C=O

Technology Process of 3,5-Bis{[tert-butyl(dimethyl)silyl]oxy}-2-fluorobenzaldehyde

There total 5 articles about 3,5-Bis{[tert-butyl(dimethyl)silyl]oxy}-2-fluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 113984-75-1
3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-fluorobenzene

: 68-12-2,33513-42-7
N,N-dimethyl-formamide

: 113984-64-8
3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-fluorobenzaldehyde

Guidance literature:: 3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-fluorobenzene; With sec.-butyllithium; In tetrahydrofuran; hexane; at -70 ℃; for 1h;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at 20 ℃; for 1.5h; Further stages.;
DOI:10.1016/j.bmc.2006.03.042

Reference yield:

: 113984-68-2
4-<(dimethyl-tert-butylsilyl)oxy>fluorobenzene

: 113984-64-8
3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-fluorobenzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: sec-BuLi / tetrahydrofuran; hexane / 0.5 h / -65 °C

1.2: trimethyl borate / tetrahydrofuran; hexane / 1 h / -65 °C

1.3: 73 percent / aq. H₂O₂; acetic acid / 0.5 h / 0 °C

2.1: 99 percent / imidazole / dimethylformamide / 1 h / 0 °C

3.1: sec-BuLi / tetrahydrofuran; hexane / 1 h / -70 °C

3.2: 92 percent / tetrahydrofuran; hexane / 1.5 h / 20 °C

With 1H-imidazole; sec.-butyllithium; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.03.042

Reference yield:

: 113984-74-0
4-(tert-butyldimethylsilyloxy)-1-fluoro-2-hydroxybenzene

: 113984-64-8
3,5-bis-(tert-butyl-dimethyl-silanyloxy)-2-fluorobenzaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: 99 percent / imidazole / dimethylformamide / 1 h / 0 °C

2.1: sec-BuLi / tetrahydrofuran; hexane / 1 h / -70 °C

2.2: 92 percent / tetrahydrofuran; hexane / 1.5 h / 20 °C

With 1H-imidazole; sec.-butyllithium; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.03.042