valproyl-2-pyrrolidinone

Base Information

• Chemical Name: valproyl-2-pyrrolidinone
• CAS No.: 120425-64-1
• Molecular Formula: C₁₂H₂₁NO₂
• Molecular Weight: 211.304
• Mol file: 120425-64-1.mol

Synonyms:valproyl-2-pyrrolidinone

Chemical Property of valproyl-2-pyrrolidinone

Chemical Property:

• Vapor Pressure: 0.00021mmHg at 25°C
• Boiling Point: 326.8°Cat760mmHg
• PKA: -1.40±0.20(Predicted)
• Flash Point: 132.6°C
• PSA: 37.38000
• Density: 1.021g/cm³
• LogP: 2.28970

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of valproyl-2-pyrrolidinone

There total 5 articles about valproyl-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

Nγ-valproyl-aminobutyric acid (122329-03-7) → 1-(2-propyl-1-pentanoyl)pyrrolidin-2-one (120425-64-1)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 24h; Heating;

DOI:10.1002/jhet.5570330372

Reference yield: 80.5%

2-pyrrolidinon (616-45-5) + valproyl chloride (2936-08-5) → 1-(2-propyl-1-pentanoyl)pyrrolidin-2-one (120425-64-1)

Guidance literature:

With triethylamine; In benzene; for 1h; Ambient temperature;

DOI:10.1007/BF00779913

Reference yield:

valproyl chloride (2936-08-5) → 1-(2-propyl-1-pentanoyl)pyrrolidin-2-one (120425-64-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) Et₃N, Me₃SiCl / 1) CH₂Cl₂, r.t., 2 h, 2) CH₂Cl₂, r.t., 46 h

2: TosOH, 2-propyl-1-pentanol / toluene / Heating

With chloro-trimethyl-silane; 2-propyl-1-pentanol; toluene-4-sulfonic acid; triethylamine; In toluene;

DOI:10.1002/ardp.19963290804

upstream raw materials:

2-pyrrolidinon

valproyl chloride

N^γ-valproyl-aminobutyric acid

valproic acid

Refernces

• 1、 Rekatas, George V.,Demopoulos, Vassilis J.,Kourounakis, Panos N.. "Synthesis of N-acyl-2-pyrrolidinones from the corresponding N-acyl-GABA derivatives". . p. 989 - 990. Retrieved 1996.