1,8-Naphthyridine-3-carboxylic acid, 1-cyclopropyl-6-fluoro-1,2-dihydro-4-hydroxy-7-[(4-methylphenyl)thio]-, ethyl ester

Base Information

Chemical Name:1,8-Naphthyridine-3-carboxylic acid, 1-cyclopropyl-6-fluoro-1,2-dihydro-4-hydroxy-7-[(4-methylphenyl)thio]-, ethyl ester
CAS No.:114171-71-0
Molecular Formula:C21H21FN2O3S
Molecular Weight:400.474
Hs Code.:
Mol file:114171-71-0.mol

Synonyms:

Suppliers and Price of 1,8-Naphthyridine-3-carboxylic acid, 1-cyclopropyl-6-fluoro-1,2-dihydro-4-hydroxy-7-[(4-methylphenyl)thio]-, ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1,8-Naphthyridine-3-carboxylic acid, 1-cyclopropyl-6-fluoro-1,2-dihydro-4-hydroxy-7-[(4-methylphenyl)thio]-, ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1,8-Naphthyridine-3-carboxylic acid, 1-cyclopropyl-6-fluoro-1,2-dihydro-4-hydroxy-7-[(4-methylphenyl)thio]-, ethyl ester

There total 12 articles about 1,8-Naphthyridine-3-carboxylic acid, 1-cyclopropyl-6-fluoro-1,2-dihydro-4-hydroxy-7-[(4-methylphenyl)thio]-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 96568-27-3
ethyl 2-amino-5-fluoro-6-(p-tolylthio)nicotinate

: 114171-71-0
ethyl 1-cyclopropyl-6-fluoro-1,2-dihydro-4-hydroxy-7-(p-tolylthio)-1,8-naphthyridine-3-carboxylate

Guidance literature:: With ethanol; sodium hydride; In toluene; for 2h; Ambient temperature;
DOI:10.1002/jhet.5570240520

Reference yield:

: 106-45-6
para-thiocresol

: 114171-71-0
ethyl 1-cyclopropyl-6-fluoro-1,2-dihydro-4-hydroxy-7-(p-tolylthio)-1,8-naphthyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 90 percent / KOH / ethanol / 2 h / Ambient temperature

2: 89 percent / KF / dimethylsulfoxide / 1 h / 130 - 135 °C

3: 84 percent / conc. H₂SO₄ / 1 h / 50 - 55 °C

4: 98 percent / BF₃-etherate / ice-cooling, then 50-60 deg C 30 min, then reflux 23 h

5: 96 percent / NaHCO₃ / dimethylformamide / 8 h / 110 - 120 °C

6: 87 percent / NaH, ethanol / toluene / 2 h / Ambient temperature

With potassium fluoride; potassium hydroxide; ethanol; sulfuric acid; boron trifluoride diethyl etherate; sodium hydride; sodium hydrogencarbonate; In ethanol; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
DOI:10.1002/jhet.5570240520

Reference yield:

: 76731-85-6
β-cyclopropylaminopropionic acid ethyl ester

: 114171-71-0
ethyl 1-cyclopropyl-6-fluoro-1,2-dihydro-4-hydroxy-7-(p-tolylthio)-1,8-naphthyridine-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / NaHCO₃ / dimethylformamide / 8 h / 110 - 120 °C

2: 87 percent / NaH, ethanol / toluene / 2 h / Ambient temperature

With ethanol; sodium hydride; sodium hydrogencarbonate; In N,N-dimethyl-formamide; toluene;
DOI:10.1002/jhet.5570240520