Technology Process of 1-Pyrrolidinecarboxylic acid,
2-[[[(3S)-1-(2-amino-2-oxoethyl)-2-oxo-3-pyrrolidinyl]amino]carbonyl]-,
phenylmethyl ester, (2S)-
There total 5 articles about 1-Pyrrolidinecarboxylic acid,
2-[[[(3S)-1-(2-amino-2-oxoethyl)-2-oxo-3-pyrrolidinyl]amino]carbonyl]-,
phenylmethyl ester, (2S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
ammonia;
In
methanol;
for 12h;
Yield given;
Ambient temperature;
DOI:10.1021/jm00402a031
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 93 percent / methanol; diethyl ether / 2 h / Ambient temperature
2: aq. HCl / dioxane / 0.33 h / 0 °C
3: diphenyl phosphorazidate, Et3N / dimethylformamide / 1) 0 deg C, 2 d; 2) room temperature, overnight
4: NH3 / methanol / 12 h / Ambient temperature
With
hydrogenchloride; diphenyl phosphoryl azide; ammonia; triethylamine;
In
1,4-dioxane; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm00402a031
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 53 percent / NaH / dimethylformamide / 1) 4 deg C, 5 min; 2) room temperature, 15 min
2: 93 percent / methanol; diethyl ether / 2 h / Ambient temperature
3: aq. HCl / dioxane / 0.33 h / 0 °C
4: diphenyl phosphorazidate, Et3N / dimethylformamide / 1) 0 deg C, 2 d; 2) room temperature, overnight
5: NH3 / methanol / 12 h / Ambient temperature
With
hydrogenchloride; diphenyl phosphoryl azide; ammonia; sodium hydride; triethylamine;
In
1,4-dioxane; methanol; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm00402a031
