2-Chloro-5-methoxyaniline

Base Information

• Chemical Name: 2-Chloro-5-methoxyaniline
• CAS No.: 2401-24-3
• Molecular Formula: C7H8ClNO
• Molecular Weight: 157.6
• Hs Code.: 2922299090
• European Community (EC) Number: 219-277-6
• UNII: 8UQ785S8U6
• DSSTox Substance ID: DTXSID70178745
• Nikkaji Number: J160.869J
• Wikidata: Q72452974
• Mol file: 2401-24-3.mol

Synonyms:2-Chloro-5-methoxyaniline;2401-24-3;6-Chloro-m-anisidine;3-Amino-4-chloroanisole;Benzenamine, 2-chloro-5-methoxy-;MFCD00047830;8UQ785S8U6;EINECS 219-277-6;6-chloro-meta-anisidine hydrochloride;2-Chloro-5-methoxyanilineHydrochloride;2-chloro-5-methoxy-aniline;2-CHLORO-5-METHOXY-PHENYLAMINE;2-chloro-5-methoxybenzenamine hydrochloride;3-methoxy-6-chloroaniline;6-chloro-3-methoxyaniline;SCHEMBL110854;UNII-8UQ785S8U6;DTXSID70178745;2-Chloro-5-methoxyaniline, 97%;2-CHLORO-5-METHOXYBENZENAMINE;AKOS009157551;AM61860;CS-W010906;AS-15825;SY008447;C3053;FT-0621076;EN300-55636;A19752;F5608-0060

Chemical Property of 2-Chloro-5-methoxyaniline

Chemical Property:

• Appearance/Colour: green gray powder.
• Vapor Pressure: 0.0168mmHg at 25°C
• Melting Point: 207 °C (dec.)(lit.)
• Refractive Index: 1.5848
• Boiling Point: 255 °C at 760 mmHg
• PKA: 2.23±0.10(Predicted)
• Flash Point: 108 °C
• PSA: 35.25000
• Density: 1.234 g/cm³
• LogP: 2.51200
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility.: Slightly soluble in water.
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 157.0294416
• Heavy Atom Count: 10
• Complexity: 110

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-5-methoxyaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi， T
• Hazard Codes: Xi,T,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-37/39-36-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)Cl)N
• Uses: 2-Chloro-5-methoxyaniline is used in the preparation of 4-amino-5-chloro-2-methoxyphenyl thiocyanate.

Technology Process of 2-Chloro-5-methoxyaniline

There total 7 articles about 2-Chloro-5-methoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-chloro-5-methoxynitrobenzene (10298-80-3) → 2-chloro-5-methoxyaniline (2401-24-3)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 95 ℃; for 12h;

DOI:10.1002/chem.201701707

Reference yield: 14.0%

2-azido-N-(2-chloro-5-methoxyphenyl)-N-methyl-2-phenylacetamide (1228378-20-8) → 6-chloro-9-methoxy-1-methyl-3-phenyl-1,4-diazaspiro[4.5]deca-3,6,9-triene-2,8-dione (1228378-54-8) + 2-chloro-5-methoxyaniline (2401-24-3) + N?methyl?2?oxo?2?phenylacetamide (83490-71-5)

Guidance literature:

With phosphate potassium salt; oxygen; copper diacetate; In N,N-dimethyl-formamide; at 80 ℃; for 10h; under 760.051 Torr;

DOI:10.1021/ja1027327

Reference yield:

4-methoxy-2-nitroaniline (96-96-8) → 2-chloro-5-methoxyaniline (2401-24-3)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) NaNO₂, aq. HCl, (ii) CuCl

2: SnCl₂, aq. HCl

With hydrogenchloride; tin(ll) chloride;

upstream raw materials:

2-chloro-5-methoxynitrobenzene

clebopride

1,3-dichloro-4-methoxybenzene

ammonia

Downstream raw materials:

2-bromo-1-chloro-4-methoxybenzene

N-(2-chloro-5-methoxyphenyl)acetamide

1-chloro-2-iodo-4-methoxybenzene

2-(2-Chloro-5-methoxy-phenylamino)-isophthalic acid