2-Hydroxy-5-(trifluoromethyl)benzene-1,3-dicarbaldehyde

Base Information

Chemical Name:2-Hydroxy-5-(trifluoromethyl)benzene-1,3-dicarbaldehyde
CAS No.:114315-20-7
Molecular Formula:C₉H₅F₃O₃
Molecular Weight:218.132
Hs Code.:
DSSTox Substance ID:DTXSID00556436
Wikidata:Q82437988
Mol file:114315-20-7.mol

Synonyms:114315-20-7;2-Hydroxy-5-(trifluoromethyl)benzene-1,3-dicarbaldehyde;2-Hydroxy-5-(trifluoromethyl)benzene-1,3-dicarboxaldehyde;1,3-Benzenedicarboxaldehyde, 2-hydroxy-5-(trifluoromethyl)-;DTXSID00556436;CTRYVVDGUDKJRD-UHFFFAOYSA-N

Suppliers and Price of 2-Hydroxy-5-(trifluoromethyl)benzene-1,3-dicarbaldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 2-Hydroxy-5-(trifluoromethyl)benzene-1,3-dicarbaldehyde

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:218.01907850
Heavy Atom Count:15
Complexity:234

Purity/Quality:: 99.90% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C=C(C(=C1C=O)O)C=O)C(F)(F)F

Technology Process of 2-Hydroxy-5-(trifluoromethyl)benzene-1,3-dicarbaldehyde

There total 7 articles about 2-Hydroxy-5-(trifluoromethyl)benzene-1,3-dicarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 118745-71-4
2,6-diformyl-4-trifluoromethylanisole

: 114315-20-7
2,6-diformyl-4-trifluoromethylphenol

: 3-Dibromomethyl-2-hydroxy-5-trifluoromethyl-benzaldehyde

Guidance literature:: With boron tribromide; In dichloromethane; for 45h; Ambient temperature;
DOI:10.1016/S0022-1139(00)81058-1

Reference yield:

: 106-41-2
4-bromo-phenol

: 114315-20-7
2,6-diformyl-4-trifluoromethylphenol

Guidance literature:: Multi-step reaction with 7 steps

1: 51 percent / potassium hydroxide / H₂O / 48 h / 35 - 40 °C

2: 46 percent / sodium hydroxide / ethanol / 3 h / Heating

3: 96 percent / pyridine / Ambient temperature

4: 95 percent / copper powder / dimethylformamide / 30 h / 150 °C / stainless steel autoclave

5: 94 percent / 5 N potassium hydroxide / ethanol / 5 h / Ambient temperature

6: 62 percent / sulfuric acid, sodium dichromate dihydrate / 1.) 110 deg C; 2.) 50 deg C, 3 h

7: 45 percent / boron tribromide / CH₂Cl₂ / 45 h / Ambient temperature

With pyridine; potassium hydroxide; sodium hydroxide; sodium dichromate; sulfuric acid; boron tribromide; copper; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/S0022-1139(00)81058-1

Reference yield:

: 6296-63-5
4-bromo-2,6-bis(hydroxymethyl)phenol

: 114315-20-7
2,6-diformyl-4-trifluoromethylphenol

Guidance literature:: Multi-step reaction with 6 steps

1: 46 percent / sodium hydroxide / ethanol / 3 h / Heating

2: 96 percent / pyridine / Ambient temperature

3: 95 percent / copper powder / dimethylformamide / 30 h / 150 °C / stainless steel autoclave

4: 94 percent / 5 N potassium hydroxide / ethanol / 5 h / Ambient temperature

5: 62 percent / sulfuric acid, sodium dichromate dihydrate / 1.) 110 deg C; 2.) 50 deg C, 3 h

6: 45 percent / boron tribromide / CH₂Cl₂ / 45 h / Ambient temperature

With pyridine; potassium hydroxide; sodium hydroxide; sodium dichromate; sulfuric acid; boron tribromide; copper; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0022-1139(00)81058-1