6296-63-5

Usage

Uses

Used in Pharmaceutical Industry:
4-Bromo-2,6-bis-hydroxymethyl-phenol is used as a key intermediate in the synthesis of various pharmaceuticals due to its unique chemical structure and properties.
Used in Antiseptic and Antibacterial Products:
4-Bromo-2,6-bis-hydroxymethyl-phenol is used as an active ingredient in antiseptic and antibacterial products for its antimicrobial properties, helping to prevent infections and maintain hygiene.
Used in Dyes and Pigments Industry:
4-Bromo-2,6-bis-hydroxymethyl-phenol is used as a colorant in the production of dyes and pigments, providing a wide range of colors and enhancing the stability of the final products.
Used in Polymer Production:
4-Bromo-2,6-bis-hydroxymethyl-phenol is used in the manufacturing of polymers, contributing to the development of new materials with improved properties and performance.
Used as a Stabilizer in Food and Beverage Industry:
4-Bromo-2,6-bis-hydroxymethyl-phenol is used as a stabilizer in the food and beverage industry to maintain the quality, taste, and shelf life of the products.
Overall, 4-Bromo-2,6-bis-hydroxymethyl-phenol exhibits a wide range of applications and properties that make it a valuable chemical compound in various industries.

InChI:InChI=1/C8H9BrO3/c9-7-1-5(3-10)8(12)6(2-7)4-11/h1-2,10-12H,3-4H2

Upstream product

• 50-00-0 formaldehyd 
• 106-41-2 4-bromo-phenol 
• 109517-99-9 2,6-diformyl-4-bromophenol 

Downstream Products

• 105375-83-5 4-bromo-2,6-bis-[2-hydroxy-3-(2-hydroxy-3,5-dimethyl-benzyl)-5-methyl-benzyl]-phenol 
• 99067-30-8 5-bromo-2-methoxyisophthalic acid 
• 71643-03-3 4-bromo-2,6-bis(5-fluoro-2-hydroxybenzyl)phenol 
• 71642-98-3 C₂₀H₁₃Br₃Cl₂O₃ 
• 71643-01-1 C₂₀H₁₃BrCl₄O₃ 
• 109517-99-9 2,6-diformyl-4-bromophenol 
• 118249-11-9 5-bromo-1,3-bis(bromomethyl)-2-methoxybenzene 
• 111171-19-8 5-Bromo-2-hydroxy-3-hydroxymethyl-benzaldehyde 
• 83142-85-2 4-bromo-2,6-bis[(5-chloro-2-hydroxyphenyl)methyl]phenol 
• 89479-09-4 [5-bromo-3-(hydroxymethyl)-2-methoxyphenyl]methanol 
• 2937-59-9 2,6-bis(hydroxymethyl)phenol 
• 173165-92-9 2,2'-[(5-bromo-2-hydroxy-1,3-phenylene)bis(methylene)]bis(4-tert-butylphenol) 
• 72109-66-1 2,6-bis(bromomethyl)-4-bromophenol 
• 206879-66-5 (5-Bromo-3-hydroxymethyl-2-methoxymethoxy-phenyl)-methanol 

Relevant academic research and scientific papers

Synthesis, spectral analysis, and thermodynamic parameters of gold(III) complex in the presence of 4-bromo-2,6-bis(hydroxymethyl)phenol and m-nitroaniline

Abstract: In the present study, we synthesized 4-bromo-2,6-bis(hydroxymethyl)phenol (BBHMP), and a gold(III) complex was synthesized in the presence of BBHMP and m-nitroaniline (m-NA). The synthesized complex was characterized using spectral (mass, UV–Vis

Bimetallic Bis-anion Cascade Complexes of Magnesium in Nonaqueous Solution

Bimetallic magnesium(II) complexes are gaining significant interest in catalysis, yet their fundamental formation and behavior in organic media remain surprisingly unexplored relative to other divalent cations. To understand key principles of their formation, we investigate symmetric ditopic ligands bearing a phenolic backbone and characterize their ability to form dinuclear magnesium(II) cascade complexes with two bridging anions. High-fidelity production of bimetallic magnesium complexes relative to the monometallic complexes is indicative of positive cooperativity. Binding and recognition of analytes or substrates is a key characteristic of metal cascade complexes and relies on anion exchange, but this is also rarely studied with bimetallic magnesium complexes. Investigations with acetate, phosphate, and pyrophosphate reveal exchange of bridging nitrates using the bis-dipicolylamine complex. Rare seven-coordinate magnesium centers are found for the ester complex. The findings in this study provide formative steps to establish design principles for future generations of bimetallic magnesium(II) complexes.

Synthesis of Monofunctionalized Calix[5]arenes

Seven OH-free and O -permethylated monofunctionalized calix[5]arenes carrying either additional methyl or tert -butyl groups are prepared following fragment condensation protocols. This strategy proves to be superior to previous approaches. Calix[5]arenes with free OH groups all adopt a cone conformation stabilized by a seam of hydrogen bonds at the lower rim. Post-condensation modifications, i.e., methylation of phenolic OH groups or functional group interconversions can also be achieved. Bulky tert -butyl groups are also found to stabilize the cone conformations of O -methylated compounds. These compounds offer versatile functional groups that make these concave molecules interesting building blocks for the synthesis of more sophisticated molecular architectures.

Self-assembly of supramolecular fractals from generation 1 to 5

In the seeking of molecular expression of fractal geometry, chemists have endeavored in the construction of molecules and supramolecules during the past few years, while only a few examples were reported, especially for the discrete architectures. We herein designed and constructed five generations of supramolecular fractals (G1-G5) based on the coordination-driven self-assembly of terpyridine ligands. All the ligands were synthesized from triphenylamine motif, which played a central role in geometry control. Different approaches based on direct Sonogashira coupling and/or (tpy-Ru(II)- tpy) connectivity were employed to prepare complex Ru(II)-organic building blocks. Fractals G1-G5 were obtained in high yields by precise coordination of organic or Ru(II)-organic building blocks with Zn(II) ions. Characterization of those architectures were accomplished by 1D and 2D NMR spectroscopy, electrospray ionization mass spectrometry (ESI-MS), traveling-wave ion mobility mass spectrometry (TWIM-MS), and transmission electron microscopy (TEM). Furthermore, the two largest fractals also hierarchically self-assemble into ordered supramolecular nanostructures either at solid/liquid interface or in solution on the basis of their well-defined scaffolds.

Synthesis and oxygen permeation of novel polymers of phenylacetylenes having two hydroxyl groups via different lengths of spacers

Three novel phenylacetylenes having two hydroxyl groups via different kinds of spacers between the two hydroxyl groups and benzyl group were synthesized and polymerized. Two of the resulting polymers having oxyalkylene spacers between the hydroxyl group a

Coordination cluster analogues of the high-Spin [Mn19] system with functionalized 2,6-Bis(hydroxymethyl)phenol ligands

A series of 2,6-bis(hydroxymethyl)-4-R-phenol ligands (H3LR; R = H, F, Cl, Br, I, Ph, NH2, NO2, SMe) have either been newly synthesized or the existing syntheses have been significantly improved to investigate ligand-functionalized analogues of the previously published coordination cluster [MnIII12MnII7(μ4-O)8(μ3-N3)8(HLMe)12(MeCN)6]Cl2·10MeOH·MeCN (1) with S = 83/2. The crystal structures and magnetic properties of three such Mn19 clusters, namely, [MnIII12MnII7(μ4-O)8(HLH)12(μ3-Cl)7(μ3-OMe)(MeOH)6]Cl2·16H2O·10MeOH·MeCN (3), [MnIII12MnII7(μ4-O)8(HLI)12(μ3-N3)8(MeOH)6](O2CH)2·16MeOH·10MeCN (4) and [MnIII12MnII7(μ4-O)8(μ3-Cl)7.7(μ3-OMe)0.3(HLSMe)12(MeOH)6]Cl2·27MeOH (5) are reported and compared to those of the parent cluster. When these ligands are functionalized with substituents of moderate electronegativity, it is possible to synthesize Mn19 analogues; however, when such ligands bear highly electron-donating (amino) or -withdrawing (nitro) substituents, the Mn19 analogues are no longer accessible. The Mn19 cluster framework is both magnetically and structurally robust with respect to the electron-donor/acceptor characteristics of the ligand substituent; therefore, the Mn19 system is an excellent platform for peripheral chemical engineering. The robustness of the inorganic {MnIII12MnII7(μ4-O)8} core of Mn19 systems with variously functionalized encapsulating ligands is demonstrated by the invariance of the record S = 83/2 spin state. Chemical modification aimed towards attaching the molecule to various substrates does not interfere with the electronic structure.

BILATERALLY-SUBSTITUTED TRICYCLIC COMPOUNDS FOR THE TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 (HIV-1) INFECTION AND OTHER DISEASES

The invention relates to bilaterally-substituted tricyclic compounds and pharmaceutical compositions containing them, for use as medicaments. Due to their ability to interact with an internal RNA loop and to mimic a protein a-helix these compounds are effective in the treatment and/or prevention of HIV-1 (Human Immunodeficiency Virus-1) infection and other diseases such as those caused by other RNA viruses and by gram-positive and gram-negative bacteria, or infectious or chronic diseases responsive to inhibition of DNA transcription, or infectious or chronic diseases where these compounds can be used to modulate the function of RNA internal loops, or infectious or chronic diseases where these compounds can be used as agonists or inhibitors of a-helical proteins in interaction with other biomolecules.

VISIBLE LIGHT ABSORBERS FOR OPHTHALMIC LENS MATERIALS

Azo compounds that block visible light are disclosed. These light absorbers are particularly suitable for use in intraocular lens materials.

Facile synthesis of an amphiphilic 1,3,5-trisubstituted benzene as a novel surface modifier by selective photocyclic aromatization and efficient improvement of oxygen permselectivity by the addition of the surface modifier

An amphiphilic 1,3,5-trisubstituted benzene as a new 2D surface modifier (T-EO) which has six hydroxy groups and three oligoethylene groups was successfully and easily synthesized by selective photocyclic aromatization in high conversion and selectivity f

Structure-based design of an RNA-binding p-terphenylene scaffold that inhibits HIV-1 rev protein function

Rev(ersing) RNA binding: RNA-binding inhibitors based on a bilaterally substituted p-terphenylene scaffold (green) project their substituents in a broad spatial angle and reproduce the interactions of a protein α-helix (red) embedded in its RNA receptor.